esxA binds B2M

Stable Identifier
R-HSA-9637635
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Mycobacterium tuberculosis
Compartment
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Mtb 6 kDa early secretory antigenic target (esxA) binds to freely available human beta-2-microglobulin (B2M) in the endoplasmic reticulum lumen, inhibiting the loading of antigen-derived peptides to B2M, a component of the class I major histocompatibility complex (MHC-I complex) (Sreejit et al. 2014).

Literature References
PubMed ID Title Journal Year
25356553 The ESAT-6 protein of Mycobacterium tuberculosis interacts with beta-2-microglobulin (β2M) affecting antigen presentation function of macrophage

Sreejit, G, Ahmed, A, Parveen, N, Jha, V, Valluri, VL, Ghosh, S, Mukhopadhyay, S

PLoS Pathog. 2014
Participants
Participant Of
Disease
Name Identifier Synonyms
tuberculosis 399 tuberculous abscess, Tuberculoma (finding), tuberculoma
Authored
Reviewed
Created
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