ATF4 and a CEBP protein bind the TRIB3 promoter

Stable Identifier
R-HSA-9635927
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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ATF4 binds composite CEBP-ATF elements located in three 33-bp tandem repeats in the promoter of the TRIB3 (TRB3, NIPK) gene (Ohoka et al. 2005, Ord and Ord 2005). ATF4 cooperates with DDIT3 to activate TRIB3 promoter activity (Ohoka et al. 2005). ATF4 also appears to bind as a heterodimer with CEBPB or CEBPG, which is required for full response to amino acid deficiency (inferred from mouse homologs).

Literature References
PubMed ID Title Journal Year
15775988 TRB3, a novel ER stress-inducible gene, is induced via ATF4-CHOP pathway and is involved in cell death

Ohoka, N, Yoshii, S, Hattori, T, Onozaki, K, Hayashi, H

EMBO J. 2005
15781252 Characterization of human NIPK (TRB3, SKIP3) gene activation in stressful conditions

Ord, D, Ord, T

Biochem. Biophys. Res. Commun. 2005
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