ATF4 and a CEBP protein bind the TRIB3 promoter

Stable Identifier
R-HSA-9635927
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
ATF4 and a CEBP protein bind the TRIB3 promoter
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

ATF4 binds composite CEBP-ATF elements located in three 33-bp tandem repeats in the promoter of the TRIB3 (TRB3, NIPK) gene (Ohoka et al. 2005, Ord and Ord 2005). ATF4 cooperates with DDIT3 to activate TRIB3 promoter activity (Ohoka et al. 2005). ATF4 also appears to bind as a heterodimer with CEBPB or CEBPG, which is required for full response to amino acid deficiency (inferred from mouse homologs).

Literature References
PubMed ID Title Journal Year
15775988 TRB3, a novel ER stress-inducible gene, is induced via ATF4-CHOP pathway and is involved in cell death

Ohoka, N, Yoshii, S, Hattori, T, Onozaki, K, Hayashi, H

EMBO J. 2005
15781252 Characterization of human NIPK (TRB3, SKIP3) gene activation in stressful conditions

Ord, D, Ord, T

Biochem. Biophys. Res. Commun. 2005
Participants
Input
Output
Participant Of
hasEvent
Inferred From
Atf4 and Cebpg bind the Trib3 gene (Mus musculus)
Authored
May, B  (2019-02-09)
Reviewed
Bruhat, A  (2019-09-15)
Chen, JJ  (2019-10-22)
Created
May, B  (2019-02-10)