esxG:esxH translocates from MTb cytosol to host phagosomal lumen

Stable Identifier
R-HSA-9635666
Type
Reaction [uncertain]
Species
Homo sapiens
Related Species
Mycobacterium tuberculosis
Compartment
Synonyms
esxG:esxH gets secreted
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The ESX-3 type VII secretion system transports the ESAT-6-like proteins esxG:esxH heterodimer from the bacterium to the host phagocytic vesicle lumen (Mehra et al. 2013, Tufariello et al. 2016).

Literature References
PubMed ID Title Journal Year
26729876 Separable roles for Mycobacterium tuberculosis ESX-3 effectors in iron acquisition and virulence

Tufariello, JM, Chapman, JR, Kerantzas, CA, Wong, KW, Vilchèze, C, Jones, CM, Cole, LE, Tinaztepe, E, Thompson, V, Fenyo, D, Niederweis, M, Ueberheide, B, Philips, JA, Jacobs, WR

Proc. Natl. Acad. Sci. U.S.A. 2016
24204276 Mycobacterium tuberculosis type VII secreted effector EsxH targets host ESCRT to impair trafficking

Mehra, A, Zahra, A, Thompson, V, Sirisaengtaksin, N, Wells, A, Porto, M, Köster, S, Penberthy, K, Kubota, Y, Dricot, A, Rogan, D, Vidal, M, Hill, DE, Bean, AJ, Philips, JA

PLoS Pathog. 2013
Participants
Participant Of
Disease
Name Identifier Synonyms
tuberculosis 399 tuberculous abscess, Tuberculoma (finding), tuberculoma
Authored
Reviewed
Created
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