EsxG:EsxH translocates from MTb cytosol to host phagosomal lumen

Stable Identifier
R-HSA-9635666
Type
Reaction [uncertain]
Species
Homo sapiens
Related Species
Mycobacterium tuberculosis
Compartment
cytosol, phagocytic vesicle lumen
Synonyms
EsxG:EsxH gets secreted
ReviewStatus
5/5
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EsxG:EsxH translocates from MTb cytosol to host phagosomal lumen
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The ESX-3 type VII secretion system transports the ESAT-6-like proteins esxG:esxH heterodimer from the bacterium to the host phagocytic vesicle lumen (Mehra et al. 2013, Tufariello et al. 2016).
Literature References
PubMed ID Title Journal Year
24204276 Mycobacterium tuberculosis type VII secreted effector EsxH targets host ESCRT to impair trafficking

Thompson, V, Vidal, M, Hill, DE, Kubota, Y, Köster, S, Penberthy, K, Porto, M, Sirisaengtaksin, N, Mehra, A, Philips, JA, Bean, AJ, Wells, A, Rogan, D, Dricot, A, Zahra, A

PLoS Pathog. 2013
26729876 Separable roles for Mycobacterium tuberculosis ESX-3 effectors in iron acquisition and virulence

Ueberheide, B, Thompson, V, Chapman, JR, Jones, CM, Tinaztepe, E, Cole, LE, Vilchèze, C, Tufariello, JM, Philips, JA, Kerantzas, CA, Jacobs, WR, Wong, KW, Fenyo, D, Niederweis, M

Proc. Natl. Acad. Sci. U.S.A. 2016
Participants
Input
Output
Participates
as an event of
Disease
Name Identifier Synonyms
tuberculosis DOID:399 tuberculous abscess, Tuberculoma (finding), tuberculoma
Authored
Stephan, R  (2019-02-06)
Reviewed
Wilkinson, RJ  (2019-10-23)
Deffur, A  (2019-10-23)
Created
Pardo, AM  (2019-02-06)
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