SHC1 binds phosphorylated ERBB2 homodimer

Stable Identifier
R-HSA-9634391
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
ReviewStatus
5/5
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SHC1 binds phosphorylated ERBB2 homodimer
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SHC1 binds to autophosphorylated ERBB2 homodimers (Pickl and Ries 2009). As PTPN12 dephosphorylates tyrosine Y1248 of ERBB2, inhibiting SHC1 binding to ERBB2 (Sun et al. 2011), and as Y1248 is autophosphorylated in ERBB2 homodimers (Pickl and Ries 2009, Maadi et al. 2018), it is assumed that PTPN12 negatively regulates SHC1 binding to ERBB2 homodimers.

Literature References
Participants
Input
Output
Participates
as an event of
This event is regulated
Negatively by
Regulator
PTPN12 [cytosol] (Homo sapiens)
Normal reaction
SHC1 binds phosphorylated ERBB2 heterodimers (Homo sapiens)
Functional status

Increased translational product level of p-ERBB2 homodimer [plasma membrane]

Normal Entity
Disease Entity
Status
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Authored
Orlic-Milacic, M  (2019-07-31)
Reviewed
Kancha, RK  (2019-09-16)
Created
Orlic-Milacic, M  (2019-01-10)
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