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p-T899-EIF2AK4 [cytosol]
Stable Identifier
R-HSA-9633781
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
fullName evidence="11"eIF-2-alpha kinase GCN2 ecNumber evidence="11"2.7.11.1/ecNumber, E2AK4_HUMAN, GCN2
Icon
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to starvation (Homo sapiens)
Response of EIF2AK4 (GCN2) to amino acid deficiency (Homo sapiens)
EIF2AK4 (GCN2) dimer autophosphorylates (Homo sapiens)
tRNA:p-T899-EIF2AK4:GCN1:80S Ribosome:mRNA [cytosol] (Homo sapiens)
tRNA:p-T899-EIF2AK4 dimer [cytosol] (Homo sapiens)
p-T899-EIF2AK4 dimer [cytosol] (Homo sapiens)
p-T899-EIF2AK4 [cytosol] (Homo sapiens)
p-T899-EIF2AK4 (GCN2) phosphorylates EIF2AS1 (Homo sapiens)
tRNA:p-T899-EIF2AK4 dimer [cytosol] (Homo sapiens)
p-T899-EIF2AK4 dimer [cytosol] (Homo sapiens)
p-T899-EIF2AK4 [cytosol] (Homo sapiens)
tRNA:p-T899-EIF2AK4:GCN1:80S Ribosome:mRNA [cytosol] (Homo sapiens)
tRNA:p-T899-EIF2AK4 dimer [cytosol] (Homo sapiens)
p-T899-EIF2AK4 dimer [cytosol] (Homo sapiens)
p-T899-EIF2AK4 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9P2K8 EIF2AK4
Gene Names
EIF2AK4, GCN2, KIAA1338
Chain
chain:1-1649
Reference Genes
BioGPS Gene:440275 EIF2AK4
COSMIC (genes):EIF2AK4 EIF2AK4
CTD Gene:440275 EIF2AK4
dbSNP Gene:440275 EIF2AK4
ENSEMBL:ENSG00000128829 EIF2AK4
HGNC:19687 EIF2AK4
KEGG:hsa:440275 EIF2AK4
Monarch:440275 EIF2AK4
NCBI Gene:440275 EIF2AK4
OMIM:609280 EIF2AK4
UCSC:Q9P2K8 EIF2AK4
Reference Transcript
RefSeq:NM_001013703.3 EIF2AK4
Other Identifiers
11754556_x_at
11760286_at
16799357
225164_3p_s_at
225164_PM_s_at
225164_s_at
237145_PM_at
237145_at
3441925
3589577
3589578
3589579
3589580
3589582
3589584
3589585
3589587
3589590
3589593
3589594
3589595
3589596
3589597
3589598
3589599
3589600
3589601
3589602
3589603
3589604
3589605
3589606
3589608
3589610
3589611
3589612
3589613
3589614
3589617
3589618
3589620
3589621
3589622
3589623
3589627
3589628
3589629
3589630
3589631
3589632
3589633
3589634
3589635
3589636
3589637
3589638
3589639
3589640
3589641
3589643
3589644
3589645
3589647
3589649
3589651
3589652
3589653
3589660
440275
52053_at
72789_at
7982620
81077_at
A_23_P54540
GE717508
GE80603
GO:0000049
GO:0000077
GO:0002230
GO:0002250
GO:0002286
GO:0002376
GO:0002821
GO:0003723
GO:0003824
GO:0004672
GO:0004674
GO:0004694
GO:0005515
GO:0005524
GO:0005634
GO:0005737
GO:0005829
GO:0005840
GO:0006355
GO:0006417
GO:0006446
GO:0006468
GO:0007399
GO:0007612
GO:0007616
GO:0010998
GO:0016740
GO:0019081
GO:0022626
GO:0032057
GO:0032792
GO:0034198
GO:0034644
GO:0036492
GO:0043226
GO:0044828
GO:0045665
GO:0045947
GO:0046777
GO:0048856
GO:0050877
GO:0051246
GO:0051607
GO:0051726
GO:0060259
GO:0061630
GO:0070417
GO:0071264
GO:0098542
GO:0106310
GO:0140096
GO:0140469
GO:1900273
GO:1990138
GO:1990625
HMNXSV003000522
HMNXSV003038429
Hs.232056.0.A1_3p_at
Hs.261587.0.S1_3p_a_at
ILMN_1755114
TC15000272.hg
Participates
as a component of
p-T899-EIF2AK4 dimer [cytosol] (Homo sapiens)
Other forms of this molecule
EIF2AK4 [cytosol]
Modified Residues
Name
O-phospho-L-threonine at 899
Coordinate
899
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Cross References
Guide to Pharmacology - Targets
2018
ENSEMBL
ENSP00000453148
,
ENST00000559624
,
ENSP00000263791
,
ENST00000263791
,
ENSG00000128829
OpenTargets
ENSG00000128829
ZINC - FDA approved
E2AK4_HUMAN
ZINC - Substances
E2AK4_HUMAN
ZINC - Biogenic
E2AK4_HUMAN
ZINC target
Q9P2K8
PRO
Q9P2K8
PDB
6N3N
,
6N3L
,
7QQ6
,
7QWK
,
7E2K
,
8T7T
,
6N3O
,
7E2M
ZINC - Investigational
E2AK4_HUMAN
GeneCards
EIF2AK4
HPA
ENSG00000128829-EIF2AK4
Pharos - Targets
Q9P2K8
ZINC - Predictions - Purchasable
E2AK4_HUMAN
HMDB Protein
HMDBP09476
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