NR1H2,3 binds the FABP6 gene

Stable Identifier
Reaction [binding]
Homo sapiens
LXR binds the FABP6 gene
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The ileal bile acid-binding protein (I-BABP, also known as FABP6) is a 14 kDa soluble bile acid (BA) carrier protein which belongs to the fatty acid-binding protein (FABP) family. FABP6 gene expression was directly up-regulated by liver X-receptor α (LXRα or NR1H3) and LXRβ (NR1H2) in human enterocyte-like Caco-2 cells when the cells were transiently cotransfected with a FABP6 promoter fragment cloned upstream of the CAT reporter gene and expression vectors for NR1H3 or NR1H2 and retinoid X receptor α (RXRα) (Landrier JF et al. 2003). Electrophoretic mobility shift assays demonstrated that the NR1H3:RXR heterodimer specifically recognized a farnesoid X‐receptor‐responsive element (FXRE) which functioned as an LXR responsive element (LXRE) in the promoter of FABP6 gene (Landrier JF et al. 2003). Similar data have been reported for the PLTP gene suggesting that the FXRE sequence can function as an LXR‐binding site in different genes (Landrier JF et al. 2002). FABP6 gene expression can be also up-regulated by sterol sensors such as farnesoid X receptor (FXR, NR1H4) or sterol-responsive element-binding protein 1c (SREBP1c) (Mak PA et al. 2002; Landrier JF et al. 2002; Zaghini I et al. 2002).

Literature References
PubMed ID Title Journal Year
14572640 FXRE can function as an LXRE in the promoter of human ileal bile acid-binding protein (I-BABP) gene

Demydchuk, J, Besnard, P, Grober, J, Landrier, JF

FEBS Lett. 2003
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