NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis

Stable Identifier
Homo sapiens
LXRs regulate gene expression to control bile acid homeostasis
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Liver X receptors NR1H3 (LXR alpha) and NR1H2 (LXR beta) are sterol-responsive transcription factors that become activated upon the engagement with their cognate oxysterol ligands. Besides inducing a genetic program aimed to reduce the cellular sterol load, ligand-activated NR1H2 & NR1H3 also modulate the expression and activity of genes controlling bile acid synthesis, transport and metabolism such as bile acid-glucuronidating enzyme UGT1A3 which converts hydrophobic bile acids into polar metabolites that can be excreted in the urine (Verreault M et al. 2006).

Literature References
PubMed ID Title Journal Year
14572640 FXRE can function as an LXRE in the promoter of human ileal bile acid-binding protein (I-BABP) gene

Landrier, JF, Grober, J, Demydchuk, J, Besnard, P

FEBS Lett. 2003
16871576 The liver X-receptor alpha controls hepatic expression of the human bile acid-glucuronidating UGT1A3 enzyme in human cells and transgenic mice

Verreault, M, Senekeo-Effenberger, K, Trottier, J, Bonzo, JA, BĂ©langer, J, Kaeding, J, Staels, B, Caron, P, Tukey, RH, Barbier, O

Hepatology 2006
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