Reactome | NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis

NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis

Stable Identifier

R-HSA-9623433

Type

Pathway

Species

Homo sapiens

Synonyms

LXRs regulate gene expression to control bile acid homeostasis

ReviewStatus

5/5

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NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis

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Liver X receptors NR1H3 (LXR alpha) and NR1H2 (LXR beta) are sterol-responsive transcription factors that become activated upon the engagement with their cognate oxysterol ligands. Besides inducing a genetic program aimed to reduce the cellular sterol load, ligand-activated NR1H2 & NR1H3 also modulate the expression and activity of genes controlling bile acid synthesis, transport and metabolism such as bile acid-glucuronidating enzyme UGT1A3 which converts hydrophobic bile acids into polar metabolites that can be excreted in the urine (Verreault M et al. 2006).

Literature References

PubMed ID	Title	Journal	Year
16871576	The liver X-receptor alpha controls hepatic expression of the human bile acid-glucuronidating UGT1A3 enzyme in human cells and transgenic mice Verreault, M, Senekeo-Effenberger, K, Trottier, J, Bonzo, JA, Bélanger, J, Kaeding, J, Staels, B, Caron, P, Tukey, RH, Barbier, O	Hepatology	2006
14572640	FXRE can function as an LXRE in the promoter of human ileal bile acid-binding protein (I-BABP) gene Landrier, JF, Grober, J, Demydchuk, J, Besnard, P	FEBS Lett.	2003