NEIL1 cleaves thymine glycol from damaged DNA

Stable Identifier
R-HSA-9629149
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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NEIL1 cleaves thymine glycol from damaged DNA
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NEIL1 cleaves thymine glycol from damaged DNA, creating an abasic (AP) site (Zhu et al. 2016).
Literature References
PubMed ID Title Journal Year
27354518 Tautomerization-dependent recognition and excision of oxidation damage in base-excision DNA repair

Zhu, C, Lu, L, Zhang, J, Yue, Z, Song, J, Zong, S, Liu, M, Stovicek, O, Gao, YQ, Yi, C

Proc. Natl. Acad. Sci. U.S.A. 2016
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Catalyst Activity

DNA N-glycosylase activity of NEIL1:Tg-dsDNA [nucleoplasm]

Physical Entity
NEIL1:Tg-dsDNA [nucleoplasm] (Homo sapiens)
Activity
DNA N-glycosylase activity (GO:0019104)
Orthologous Events
NEIL1 cleaves thymine glycol from damaged DNA (Bos taurus)
NEIL1 cleaves thymine glycol from damaged DNA (Canis familiaris)
NEIL1 cleaves thymine glycol from damaged DNA (Danio rerio)
NEIL1 cleaves thymine glycol from damaged DNA (Gallus gallus)
NEIL1 cleaves thymine glycol from damaged DNA (Mus musculus)
NEIL1 cleaves thymine glycol from damaged DNA (Rattus norvegicus)
NEIL1 cleaves thymine glycol from damaged DNA (Sus scrofa)
NEIL1 cleaves thymine glycol from damaged DNA (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2018-11-27)
Reviewed
Sampath, H  (2019-01-03)
Created
Orlic-Milacic, M  (2018-11-19)
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