Reactome | CEBPA binds CDK2

CEBPA binds CDK2

Stable Identifier

R-HSA-9624120

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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CEBPA binds CDK2 and disrupts CDK2:cyclin complexes thereby inhibiting kinase activity of CDK2, which may contribute to the inhibition of cellular proliferation observed in response to CEBPA (Wang et al. 2001). CEBPA interacts with the T loop region of CDK2. In mouse liver cells, 35%-50% of Cdk2 is associated with Cebpa (Wang et al. 2001).

Literature References

PubMed ID	Title	Journal	Year
11684017	C/EBPalpha arrests cell proliferation through direct inhibition of Cdk2 and Cdk4 Wang, H, Iakova, P, Wilde, M, Welm, A, Goode, T, Roesler, WJ, Timchenko, NA	Mol. Cell	2001
11369759	CCAAT/enhancer-binding protein-alpha cooperates with p21 to inhibit cyclin-dependent kinase-2 activity and induces growth arrest independent of DNA binding Harris, TE, Albrecht, JH, Nakanishi, M, Darlington, GJ	J. Biol. Chem.	2001