CEBPA binds CDK2 and disrupts CDK2:cyclin complexes thereby inhibiting kinase activity of CDK2, which may contribute to the inhibition of cellular proliferation observed in response to CEBPA (Wang et al. 2001). CEBPA interacts with the T loop region of CDK2. In mouse liver cells, 35%-50% of Cdk2 is associated with Cebpa (Wang et al. 2001).