CEBPA binds CDK2

Stable Identifier
R-HSA-9624120
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

CEBPA binds CDK2 and disrupts CDK2:cyclin complexes thereby inhibiting kinase activity of CDK2, which may contribute to the inhibition of cellular proliferation observed in response to CEBPA (Wang et al. 2001). CEBPA interacts with the T loop region of CDK2. In mouse liver cells, 35%-50% of Cdk2 is associated with Cebpa (Wang et al. 2001).

Literature References
PubMed ID Title Journal Year
11369759 CCAAT/enhancer-binding protein-alpha cooperates with p21 to inhibit cyclin-dependent kinase-2 activity and induces growth arrest independent of DNA binding

Harris, TE, Albrecht, JH, Nakanishi, M, Darlington, GJ

J. Biol. Chem. 2001
11684017 C/EBPalpha arrests cell proliferation through direct inhibition of Cdk2 and Cdk4

Wang, H, Iakova, P, Wilde, M, Welm, A, Goode, T, Roesler, WJ, Timchenko, NA

Mol. Cell 2001
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created