Reactome | CEBPA binds CDK4

CEBPA binds CDK4

Stable Identifier

R-HSA-9624112

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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CEBPA binds CDK4, inhibits the kinase activity of CDK4, and enhances the proteasomal degradation of CDK4 (Wang et al. 2001, Wang et al. 2002). These mechanisms may contribute to the inhibition of cell proliferation observed in response to CEBPA. CEBPA interacts with the T loop region of CDK4. In mouse liver cells, 5%-10% of Cdk4 is associated with Cebpa (Wang et al. 2001).

Literature References

PubMed ID	Title	Journal	Year
11684017	C/EBPalpha arrests cell proliferation through direct inhibition of Cdk2 and Cdk4 Wang, H, Iakova, P, Wilde, M, Welm, A, Goode, T, Roesler, WJ, Timchenko, NA	Mol. Cell	2001
11867521	C/EBPalpha triggers proteasome-dependent degradation of cdk4 during growth arrest Wang, H, Goode, T, Iakova, P, Albrecht, JH, Timchenko, NA	EMBO J.	2002