HSPA8:Substrate binds LAMP2a

Stable Identifier
R-HSA-9620197
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Intracellular proteins are targeted for proteolytic degradation in lysosome with the aid of chaperones. Heat shock cognate 71 kDa protein (HSPA8) acts as the constitutive chaperone that binds substrates in the cytosol. Consequently, the Hspa8:Substrate complex translocates from cytosol to lysosomal membrane where it binds to Lysosome-associated membrane glycoprotein 2 (LAMP2a) (Cuervo AM and Dice JF. 1996). Four positively charged amino acids in the cytosolic tail of the LAMP2a isoform is known to regulate the binding mechanism (Cuervo AM and Dice JF. 2000). Experiments confirming this binding were performed on rat models.

Literature References
PubMed ID Title Journal Year
11082038 Unique properties of lamp2a compared to other lamp2 isoforms

Cuervo, AM, Dice, JF

J. Cell. Sci. 2000
8662539 A receptor for the selective uptake and degradation of proteins by lysosomes

Cuervo, AM, Dice, JF

Science 1996
Participants
Participant Of
Inferred From
Authored
Reviewed
Created