Based on studies in mouse cells, L-PRX co-immunoprecipitates in a complex that includes DRP2, alpha- and beta-dystroglycan and dystrophin family utrophin (UTRN) (Sherman et al, 2001; reviewed in Wrabetz and Feltri, 2001; Masaki and Matsumura, 2010). Because UTRN does not interact directly with L-PRX, it is possible they are recruited indirectly through as part of alternate DGC complexes with varied dystrophin family members. This model remains to be validated, however (Sherman et al, 2001).
Wrabetz, L, Feltri, ML
Gillespie, CS, Fabrizi, C, Brophy, PJ, Sherman, DL
Matsumura, K, Masaki, T
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