Reactome | L-PRX:DRP:DGC:laminin-211 interacts with UTRN

L-PRX:DRP:DGC:laminin-211 interacts with UTRN

Stable Identifier

R-HSA-9619668

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

plasma membrane, cytosol, extracellular region

ReviewStatus

5/5

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L-PRX:DRP:DGC:laminin-211 interacts with UTRN

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Based on studies in mouse cells, L-PRX co-immunoprecipitates in a complex that includes DRP2, alpha- and beta-dystroglycan and dystrophin family utrophin (UTRN) (Sherman et al, 2001; reviewed in Wrabetz and Feltri, 2001; Masaki and Matsumura, 2010). Because UTRN does not interact directly with L-PRX, it is possible they are recruited indirectly through as part of alternate DGC complexes with varied dystrophin family members. This model remains to be validated, however (Sherman et al, 2001).

Literature References

PubMed ID	Title	Journal	Year
11430795	Do Schwann cells stop, DR(o)P2, and roll? Wrabetz, L, Feltri, ML	Neuron	2001
11430802	Specific disruption of a schwann cell dystrophin-related protein complex in a demyelinating neuropathy Gillespie, CS, Fabrizi, C, Brophy, PJ, Sherman, DL	Neuron	2001
20625412	Biological role of dystroglycan in Schwann cell function and its implications in peripheral nervous system diseases Matsumura, K, Masaki, T	J. Biomed. Biotechnol.	2010