L-PRX:DRP:DGC:laminin-211 interacts with UTRN

Stable Identifier
R-HSA-9619668
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
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Based on studies in mouse cells, L-PRX co-immunoprecipitates in a complex that includes DRP2, alpha- and beta-dystroglycan and dystrophin family utrophin (UTRN) (Sherman et al, 2001; reviewed in Wrabetz and Feltri, 2001; Masaki and Matsumura, 2010). Because UTRN does not interact directly with L-PRX, it is possible they are recruited indirectly through as part of alternate DGC complexes with varied dystrophin family members. This model remains to be validated, however (Sherman et al, 2001).

Literature References
PubMed ID Title Journal Year
11430802 Specific disruption of a schwann cell dystrophin-related protein complex in a demyelinating neuropathy

Sherman, DL, Fabrizi, C, Gillespie, CS, Brophy, PJ

Neuron 2001
11430795 Do Schwann cells stop, DR(o)P2, and roll?

Wrabetz, L, Feltri, ML

Neuron 2001
20625412 Biological role of dystroglycan in Schwann cell function and its implications in peripheral nervous system diseases

Masaki, T, Matsumura, K

J. Biomed. Biotechnol. 2010
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