CAMKK2 phosphorylates AMPK

Stable Identifier
R-HSA-9619478
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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CAMKK2 phosphorylates AMPK
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Activated CAMKK2 (CaMKK-beta) phosphorylates the alpha subunit of AMP-activated kinase (AMPK). The CAMKK2 target site is evolutionarily conserved in two AMPK-alpha isoforms and corresponds to threonine 183 (T183) in PRKAA1 (AMPK-alpha1) and threonine 172 (T172) in PRKAA2 (AMPK-alpha2).

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Input
Output
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as an event of
Catalyst Activity

calmodulin-dependent protein kinase activity of p-CAMKK2:CALM1:4xCa2+ [cytosol]

Physical Entity
p-CAMKK2:CALM1:4xCa2+ [cytosol] (Homo sapiens)
Activity
calmodulin-dependent protein kinase activity (GO:0004683)
Inferred From
Camkk2 phosphorylates AMPK (Rattus norvegicus)
Authored
Orlic-Milacic, M  (2018-10-10)
Reviewed
Hansen, KB  (2018-11-02)
Yi, F  (2018-11-02)
Created
Orlic-Milacic, M  (2018-09-17)
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