Reactome | CAMK1 binds calmodulin

CAMK1 binds calmodulin

Stable Identifier

R-HSA-9619376

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

Locations in the PathwayBrowser

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Neuronal System (Homo sapiens)

- Transmission across Chemical Synapses (Homo sapiens)
  - Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
    - Activation of NMDA receptors and postsynaptic events (Homo sapiens)
      - Post NMDA receptor activation events (Homo sapiens)
        
        Activation of RAC1 downstream of NMDARs (Homo sapiens)
        
        CAMK1 binds calmodulin (Homo sapiens)

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Activated calmodulin (CALM1:4xCa2+) binds to the C-terminal region of CAMK1 (CaMKI). Calmodulin binding exposes CaMKK target site, threonine T177, on CAMK1 (Haribabu et al. 1995).

Literature References

PubMed ID	Title	Journal	Year
7641687	Human calcium-calmodulin dependent protein kinase I: cDNA cloning, domain structure and activation by phosphorylation at threonine-177 by calcium-calmodulin dependent protein kinase I kinase Haribabu, B, Hook, SS, Selbert, MA, Goldstein, EG, Tomhave, ED, Edelman, AM, Snyderman, R, Means, AR	EMBO J.	1995