Activation of RAC1 downstream of NMDARs

Stable Identifier
R-HSA-9619229
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Pathway
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Homo sapiens
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Activation of calcium/calmodulin-dependent kinase kinases, CaMKKs (CAMKK1 and CAMKK2), upon calcium influx through activated NMDA receptors, leads to activation of the cytosolic calcium/calmodulin kinase CaMKI (CAMK1). One of the CAMK1 targets is the RAC1 guanine nucleotide exchange factor ARHGEF7 (beta-Pix). Activation of RAC1 is involved in NMDA-receptor triggered synaptogenesis (Saneyoshi et al. 2008).

Literature References
PubMed ID Title Journal Year
18184567 Activity-dependent synaptogenesis: regulation by a CaM-kinase kinase/CaM-kinase I/betaPIX signaling complex

Saneyoshi, T, Wayman, G, Fortin, D, Davare, M, Hoshi, N, Nozaki, N, Natsume, T, Soderling, TR

Neuron 2008
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