Activation of RAC1 downstream of NMDARs

Stable Identifier
R-HSA-9619229
Type
Pathway
Species
Homo sapiens
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Activation of RAC1 downstream of NMDARs
Click the image above or here to open this pathway in the Pathway Browser

Activation of calcium/calmodulin-dependent kinase kinases, CaMKKs (CAMKK1 and CAMKK2), upon calcium influx through activated NMDA receptors, leads to activation of the cytosolic calcium/calmodulin kinase CaMKI (CAMK1). One of the CAMK1 targets is the RAC1 guanine nucleotide exchange factor ARHGEF7 (beta-Pix). Activation of RAC1 is involved in NMDA-receptor triggered synaptogenesis (Saneyoshi et al. 2008).

Literature References
PubMed ID Title Journal Year
18184567 Activity-dependent synaptogenesis: regulation by a CaM-kinase kinase/CaM-kinase I/betaPIX signaling complex

Natsume, T, Fortin, D, Davare, M, Soderling, TR, Nozaki, N, Wayman, G, Saneyoshi, T, Hoshi, N

Neuron 2008
Participants
Events
Participates
as an event of
Event Information
Go Biological Process
chemical synaptic transmission (0007268)
Orthologous Events
Activation of RAC1 downstream of NMDARs (Bos taurus)
Activation of RAC1 downstream of NMDARs (Caenorhabditis elegans)
Activation of RAC1 downstream of NMDARs (Canis familiaris)
Activation of RAC1 downstream of NMDARs (Danio rerio)
Activation of RAC1 downstream of NMDARs (Dictyostelium discoideum)
Activation of RAC1 downstream of NMDARs (Drosophila melanogaster)
Activation of RAC1 downstream of NMDARs (Gallus gallus)
Activation of RAC1 downstream of NMDARs (Mus musculus)
Activation of RAC1 downstream of NMDARs (Plasmodium falciparum)
Activation of RAC1 downstream of NMDARs (Rattus norvegicus)
Activation of RAC1 downstream of NMDARs (Saccharomyces cerevisiae)
Activation of RAC1 downstream of NMDARs (Schizosaccharomyces pombe)
Activation of RAC1 downstream of NMDARs (Sus scrofa)
Cross References
BioModels Database
Authored
Orlic-Milacic, M  (2018-10-11)
Reviewed
Hansen, KB  (2018-11-02)
Yi, F  (2018-11-02)
Created
Orlic-Milacic, M  (2018-09-14)
Cite Us!