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Calmodulin binds neurogranin
Stable Identifier
R-HSA-9618785
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
Synonyms
CALM1 binds NRGN
ReviewStatus
5/5
Locations in the PathwayBrowser
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Neuronal System (Homo sapiens)
Transmission across Chemical Synapses (Homo sapiens)
Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
Activation of NMDA receptors and postsynaptic events (Homo sapiens)
Post NMDA receptor activation events (Homo sapiens)
Long-term potentiation (Homo sapiens)
Calmodulin binds neurogranin (Homo sapiens)
General
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SBGN
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In the absence of calcium (Ca2+), calmodulin (CALM1) binds to neurogranin (NRGN) (Seeger et al. 2017). NRGN is enriched in dendritic spines where it slows down the diffusion rate of CALM1. NRGN increases the local concentration of CALM1 and enhances Ca2+ sensitivity at the synapse, thereby enhancing synaptic strength. The association between NRGN and CALM1 is dynamic, and NRGN does not sequester CALM1 (Petersen and Gerges 2015). Nrgn knockout mice exhibit impaired synaptic plasticity and spatial learning, with reduced ability to generate activated CaMKII after stimulation (Pak et al. 2000).
Literature References
PubMed ID
Title
Journal
Year
28449373
Biophysical analysis of the dynamics of calmodulin interactions with neurogranin and Ca
2+
/calmodulin-dependent kinase II
Seeger, C
,
Talibov, VO
,
Danielson, UH
J. Mol. Recognit.
2017
Participants
Input
CALM1 [cytosol]
(Homo sapiens)
NRGN [cytosol]
(Homo sapiens)
Output
CALM1:NRGN [cytosol]
(Homo sapiens)
Participates
as an event of
Long-term potentiation (Homo sapiens)
Authored
Orlic-Milacic, M (2018-10-10)
Reviewed
Hansen, KB (2018-11-02)
Yi, F (2018-11-02)
Created
Orlic-Milacic, M (2018-09-12)
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