MIR137 gene expression is inhibited by MECP2 and SOX2

Stable Identifier
R-HSA-9615554
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
MIR137 gene expression is inhibited by MECP2 and SOX2
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Based on studies in mouse neurons, MECP2 and SOX2 directly repress transcription from the MIR137 gene, encoding microRNA miR-137 (Szulwach et al. 2010, Lyu et al. 2016).
Participants
Input
Output
Participates
as an event of
This event is regulated
Negatively by
Regulator
MECP2:SOX2:MIR137 gene [nucleoplasm] (Homo sapiens)
Active Unit
SOX2 [nucleoplasm]
MECP2 [nucleoplasm]
Inferred From
Mir137 gene expression is inhibited by Mecp2 and Sox2 (Mus musculus)
Authored
Orlic-Milacic, M  (2018-08-08)
Reviewed
Krishnaraj, R  (2018-08-07)
Christodoulou, J  (2018-08-07)
Created
Orlic-Milacic, M  (2018-08-07)
Cite Us!