Mir137 gene expression is inhibited by Mecp2 and Sox2

Stable Identifier
R-MMU-9615658
Type
Reaction [omitted]
Species
Mus musculus
Compartment
nucleoplasm, cytosol
ReviewStatus
5/5
General
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PNG
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High
 | PPTX  | SBGN
Mir137 gene expression is inhibited by Mecp2 and Sox2
In mouse neurons, Mecp1 and Sox2 directly repress transcription from the Mir137 gene, encoding microRNA miR-137 (Szulwach et al. 2010, Lyu et al. 2016).
Literature References
PubMed ID Title Journal Year
20368621 Cross talk between microRNA and epigenetic regulation in adult neurogenesis

Li, X, Jin, P, Smrt, RD, Lin, L, Li, W, Li, Y, Zhao, X, Luo, Y, Santistevan, NJ, Szulwach, KE

J. Cell Biol. 2010
26843422 Reciprocal regulation of autism-related genes MeCP2 and PTEN via microRNAs

Lyu, JW, Zhou, WH, Qiu, ZL, Cheng, TL, Yuan, B

Sci Rep 2016
Participants
Input
Output
This event is regulated
Negatively by
Regulator
Mecp2:Sox2:Mir137 gene [nucleoplasm] (Mus musculus)
Active Unit
Sox2 [nucleoplasm]
Mecp2 [nucleoplasm]
Orthologous Events
MIR137 gene expression is inhibited by MECP2 and SOX2 (Homo sapiens)
Authored
Orlic-Milacic, M  (2017-10-02)
Reviewed
Krishnaraj, R  (2018-08-07)
Christodoulou, J  (2018-08-07)
Created
Orlic-Milacic, M  (2018-08-08)
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