Based on studies in rat and mouse cells, CREB1 induces transcription of the MIR132 gene, encoding miR-132 microRNA (Vo et al. 2005, Lyu et al. 2016). Activation of CREB1 by phosphorylation at serine residue S133 in response to PTEN knockdown results in increased levels of miR-132 (Lyu et al. 2016).