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AGT(25-32) binds to AGTR2
Stable Identifier
R-HSA-9615348
Type
Reaction [binding]
Species
Homo sapiens
Compartment
extracellular region
,
plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
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Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Peptide ligand-binding receptors (Homo sapiens)
AGT(25-32) binds to AGTR2 (Homo sapiens)
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The cardiovascular and other actions of the vasoconstricting peptide angiotensin II are mediated by the type 1 and type 2 angiotensin II receptors (AT1 and AT2), which are seven transmembrane glycoproteins with 30% sequence similarity. AT1 receptors (Bergsma DJ et al, 1992) couple to G(q/11), and signal through phospholipases A, C, D, inositol phosphates, calcium channels, and a variety of serine/threonine and tyrosine kinases. The AT2 receptor (Tsuzuki S et al, 1994) is expressed mainly during fetal development. It is much less abundant in adult tissues and is up-regulated in pathological conditions. Its signaling pathways include serine and tyrosine phosphatases, phospholipase A2, nitric oxide, and cyclic guanosine monophosphate. The AT2 receptor counteracts several of the growth responses initiated by the AT1 and growth factor receptors.
Literature References
PubMed ID
Title
Journal
Year
8185599
Molecular cloning and expression of the gene encoding human angiotensin II type 2 receptor
Ichiki, T
,
Tsuzuki, S
,
Kitami, Y
,
Guo, DF
,
Shirai, H
,
Nakakubo, H
,
Inagami, T
Biochem Biophys Res Commun
1994
Participants
Input
AGT(25-32) [extracellular region]
(Homo sapiens)
AGTR2 [plasma membrane]
(Homo sapiens)
Output
AGTR2:AGT(25-32) [plasma membrane]
(Homo sapiens)
Participates
as an event of
Peptide ligand-binding receptors (Homo sapiens)
Orthologous Events
AGT(25-32) binds to AGTR2 (Bos taurus)
AGT(25-32) binds to AGTR2 (Caenorhabditis elegans)
AGT(25-32) binds to AGTR2 (Canis familiaris)
AGT(25-32) binds to AGTR2 (Danio rerio)
AGT(25-32) binds to AGTR2 (Drosophila melanogaster)
AGT(25-32) binds to AGTR2 (Gallus gallus)
AGT(25-32) binds to AGTR2 (Mus musculus)
AGT(25-32) binds to AGTR2 (Rattus norvegicus)
AGT(25-32) binds to AGTR2 (Sus scrofa)
Authored
Jassal, B (2008-08-21)
Reviewed
Bockaert, J (2008-09-01)
Created
Jassal, B (2018-08-02)
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