PLINs bind HSPA8

Stable Identifier
R-HSA-9613352
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol, lipid droplet
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
PLINs bind HSPA8
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Lipophagy is the process of autophagic degradation of lipid droplets into fatty acids. A key step in this process is the elimination of perilipin (PLIN) proteins on lipid droplet surface. This mechanism is initiated when the cytosolic Heat shock cognate 71 kDa protein (HSPA8) binds PLIN2 and PLIN3 on the lipid droplet surface. Consequently, perilipins are phosphorylated and targeted to degradation making the lipid available for hydrolysis (S Kaushik et al. 2015). Experiments confirming this interaction were performed in rats.

Literature References
PubMed ID Title Journal Year
25961502 Degradation of lipid droplet-associated proteins by chaperone-mediated autophagy facilitates lipolysis

Cuervo, AM, Kaushik, S

Nat. Cell Biol. 2015
Participants
Input
Output
Participates
as an event of
Inferred From
Plins bind Hspa8 (Rattus norvegicus)
Authored
Varusai, TM  (2019-02-21)
Reviewed
Metzakopian, E  (2019-02-22)
Created
Varusai, TM  (2018-07-13)
Cite Us!