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PLINs bind HSPA8
Stable Identifier
R-HSA-9613352
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
,
lipid droplet
ReviewStatus
5/5
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Autophagy (Homo sapiens)
Macroautophagy (Homo sapiens)
Selective autophagy (Homo sapiens)
Lipophagy (Homo sapiens)
PLINs bind HSPA8 (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Lipophagy is the process of autophagic degradation of lipid droplets into fatty acids. A key step in this process is the elimination of perilipin (PLIN) proteins on lipid droplet surface. This mechanism is initiated when the cytosolic Heat shock cognate 71 kDa protein (HSPA8) binds PLIN2 and PLIN3 on the lipid droplet surface. Consequently, perilipins are phosphorylated and targeted to degradation making the lipid available for hydrolysis (S Kaushik et al. 2015). Experiments confirming this interaction were performed in rats.
Literature References
PubMed ID
Title
Journal
Year
25961502
Degradation of lipid droplet-associated proteins by chaperone-mediated autophagy facilitates lipolysis
Cuervo, AM
,
Kaushik, S
Nat. Cell Biol.
2015
Participants
Input
HSPA8 [cytosol]
(Homo sapiens)
PLINs on lipid droplet surface [lipid droplet]
(Homo sapiens)
Output
PLINs:HSPA8 [lipid droplet]
(Homo sapiens)
Participates
as an event of
Lipophagy (Homo sapiens)
Inferred From
Plins bind Hspa8 (Rattus norvegicus)
Authored
Varusai, TM (2019-02-21)
Reviewed
Metzakopian, E (2019-02-22)
Created
Varusai, TM (2018-07-13)
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