PLINs bind HSPA8

Stable Identifier
R-HSA-9613352
Type
Reaction [binding]
Species
Homo sapiens
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Lipophagy is the process of autophagic degradation of lipid droplets into fatty acids. A key step in this process is the elimination of perilipin (PLIN) proteins on lipid droplet surface. This mechanism is initiated when the cytosolic Heat shock cognate 71 kDa protein (HSPA8) binds PLIN2 and PLIN3 on the lipid droplet surface. Consequently, perilipins are phosphorylated and targeted to degradation making the lipid available for hydrolysis (S Kaushik et al. 2015). Experiments confirming this interaction were performed in rats.

Literature References
PubMed ID Title Journal Year
25961502 Degradation of lipid droplet-associated proteins by chaperone-mediated autophagy facilitates lipolysis

Kaushik, S, Cuervo, AM

Nat. Cell Biol. 2015
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