Lipophagy

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Triglycerides stored in lipid droplets are hydrolysed under nutrient starvation to release fatty acids for energy. The content of lipid droplets may vary but they are all coated with a protective protein called perilipin. When this protein is degraded, lipid droplets associate with autophagic components and breakdown into fatty acids (Ward C et al. 2016, Schulze R J et al. 2017). This process is termed as lipophagy (Singh R et al. 2009).

Literature References
PubMed ID Title Journal Year
28642194 Breaking fat: The regulation and mechanisms of lipophagy

Schulze, RJ, Sathyanarayan, A, Mashek, DG

Biochim. Biophys. Acta 2017
19339967 Autophagy regulates lipid metabolism

Singh, R, Kaushik, S, Wang, Y, Xiang, Y, Novak, I, Komatsu, M, Tanaka, K, Cuervo, AM, Czaja, MJ

Nature 2009
26778751 Autophagy, lipophagy and lysosomal lipid storage disorders

Ward, C, Martinez-Lopez, N, Otten, EG, Carroll, B, Maetzel, D, Singh, R, Sarkar, S, Korolchuk, VI

Biochim. Biophys. Acta 2016
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