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Triglycerides stored in lipid droplets are hydrolysed under nutrient starvation to release fatty acids for energy. The content of lipid droplets may vary but they are all coated with a protective protein called perilipin. When this protein is degraded, lipid droplets associate with autophagic components and breakdown into fatty acids (Ward C et al. 2016, Schulze R J et al. 2017). This process is termed as lipophagy (Singh R et al. 2009).

Literature References
PubMed ID Title Journal Year
19339967 Autophagy regulates lipid metabolism

Czaja, MJ, Cuervo, AM, Novak, I, Komatsu, M, Tanaka, K, Kaushik, S, Singh, R, Wang, Y, Xiang, Y

Nature 2009
28642194 Breaking fat: The regulation and mechanisms of lipophagy

Mashek, DG, Sathyanarayan, A, Schulze, RJ

Biochim. Biophys. Acta 2017
26778751 Autophagy, lipophagy and lysosomal lipid storage disorders

Ward, C, Martinez-Lopez, N, Carroll, B, Maetzel, D, Singh, R, Korolchuk, VI, Sarkar, S, Otten, EG

Biochim. Biophys. Acta 2016
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