ERBB4 binds DLG4

Stable Identifier
R-HSA-9612593
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
ERBB4 binds PSD-95
ReviewStatus
5/5
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ERBB4 binds DLG4
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ERBB4 can bind to a postsynaptic density (PSD) protein DLG4 (PSD-95) (Huang et al. 2000, Garcia et al. 2000). Binding to DLG4 enables ERBB4 to localize to the PSD, where it can modulate the activity of neurotransmitter receptors, but most ERBB4 receptors are found outside of the PSD in neuronal cells (Mitchell et al. 2013). One molecule of DLG4 can bind two molecules of ERBB4, which may facilitate ERBB4 dimerization upon ligand binding (Huang et al. 2000).
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Output
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as an event of
Inferred From
Erbb4 binds Dlg4 (Rattus norvegicus)
Authored
Stern, DF  (2019-02-21)
Orlic-Milacic, M  (2018-06-28)
Created
Orlic-Milacic, M  (2018-06-28)
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