ERBB4 binds DLG4

Stable Identifier
R-HSA-9612593
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Synonyms
ERBB4 binds PSD-95
ReviewStatus
5/5
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
ERBB4 can bind to a postsynaptic density (PSD) protein DLG4 (PSD-95) (Huang et al. 2000, Garcia et al. 2000). Binding to DLG4 enables ERBB4 to localize to the PSD, where it can modulate the activity of neurotransmitter receptors, but most ERBB4 receptors are found outside of the PSD in neuronal cells (Mitchell et al. 2013). One molecule of DLG4 can bind two molecules of ERBB4, which may facilitate ERBB4 dimerization upon ligand binding (Huang et al. 2000).
Participants
Participates
Inferred From
Authored
Created
Cite Us!