β1-agonists bind ADRB1

Stable Identifier
R-HSA-9611721
Type
Reaction [binding]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
β-adrenergic receptor agonists (β-agonists) mimic the action of epinephrine and norepinephrine signaling in the heart, lungs and smooth muscle tissue and have the opposite function to β-blockers. Selective activation of β1 receptors induces positive inotropic and chronotropic output of the cardiac muscle, leading to increased heart rate and blood pressure (Isogaya et al. 1999). Selective β-agonists include denopamine, xamoterol and prenalterol.

Denopamine is a selective β1-adrenergic agonist with low intrinsic activity that is less prone than full agonists to cause desensitization (Suzuki et al. 1993). Xamoterol is a 3rd generation β1-adrenergic partial agonist that acts as a cardiac stimulant and improves both systolic and diastolic function in patients with heart failure (Marlow 1989). Prenalterol acts as a β1-adrenergic partial agonist (Wirtzfeld et al. 1985) and can be used in patients with chronic heart failure (Sharpe & Coxon 1983).
Literature References
PubMed ID Title Journal Year
10531390 Binding pockets of the beta(1)- and beta(2)-adrenergic receptors for subtype-selective agonists

Tanaka, R, Sugimoto, Y, Kurose, H, Kikkawa, H, Isogaya, M, Tanimura, R, Nagao, T

Mol. Pharmacol. 1999
Participants
Participates
Orthologous Events
Authored
Reviewed
Created
Cite Us!