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β1-agonists bind ADRB1
Stable Identifier
R-HSA-9611721
Type
Reaction [binding]
Species
Homo sapiens
Compartment
extracellular region
,
plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
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Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Amine ligand-binding receptors (Homo sapiens)
Adrenoceptors (Homo sapiens)
β1-agonists bind ADRB1 (Homo sapiens)
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β-adrenergic receptor agonists (β-agonists) mimic the action of epinephrine and norepinephrine signaling in the heart, lungs and smooth muscle tissue and have the opposite function to β-blockers. Selective activation of β1 receptors induces positive inotropic and chronotropic output of the cardiac muscle, leading to increased heart rate and blood pressure (Isogaya et al. 1999). Selective β-agonists include denopamine, xamoterol and prenalterol.
Denopamine is a selective β1-adrenergic agonist with low intrinsic activity that is less prone than full agonists to cause desensitization (Suzuki et al. 1993). Xamoterol is a 3rd generation β1-adrenergic partial agonist that acts as a cardiac stimulant and improves both systolic and diastolic function in patients with heart failure (Marlow 1989). Prenalterol acts as a β1-adrenergic partial agonist (Wirtzfeld et al. 1985) and can be used in patients with chronic heart failure (Sharpe & Coxon 1983).
Literature References
PubMed ID
Title
Journal
Year
10531390
Binding pockets of the beta(1)- and beta(2)-adrenergic receptors for subtype-selective agonists
Tanaka, R
,
Sugimoto, Y
,
Kurose, H
,
Kikkawa, H
,
Isogaya, M
,
Tanimura, R
,
Nagao, T
Mol. Pharmacol.
1999
Participants
Input
ADRB1 [plasma membrane]
(Homo sapiens)
β1-agonists [extracellular region]
(Homo sapiens)
Output
β1-agonists:ADBR1 [plasma membrane]
(Homo sapiens)
Participates
as an event of
Adrenoceptors (Homo sapiens)
Orthologous Events
β1-agonists bind ADRB1 (Bos taurus)
β1-agonists bind ADRB1 (Danio rerio)
β1-agonists bind ADRB1 (Drosophila melanogaster)
β1-agonists bind ADRB1 (Gallus gallus)
β1-agonists bind ADRB1 (Mus musculus)
β1-agonists bind ADRB1 (Rattus norvegicus)
β1-agonists bind ADRB1 (Sus scrofa)
β1-agonists bind ADRB1 (Xenopus tropicalis)
Authored
Jassal, B (2018-06-19)
Reviewed
Huddart, R (2022-03-01)
Created
Jassal, B (2018-06-19)
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