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Fusion of HCMV Envelope with Plasma Membrane
Stable Identifier
R-HSA-9611158
Type
Reaction [dissociation]
Species
Homo sapiens
Related Species
Human cytomegalovirus
Compartment
plasma membrane
ReviewStatus
5/5
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Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
HCMV Infection (Homo sapiens)
HCMV Early Events (Homo sapiens)
Fusion of HCMV Envelope with Plasma Membrane (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Once Human cytomegalovirus (HCMV) initial attachs to cell surface heparan sulfate proteoglycans (HSPGs), the virus fuses with thecell membrane.
Literature References
PubMed ID
Title
Journal
Year
Fields Virology
Knipe, DM
,
Howley, PM
2013
Participants
Input
Enveloped HCMV Virion without Pentameric Complex Bound to Entry Mediator [extracellular region]
(Homo sapiens)
Output
gB Homodimer [plasma membrane]
(Human cytomegalovirus)
gH:gL:gO (gCIII) [plasma membrane]
(Human cytomegalovirus)
gM:gN [plasma membrane]
(Human cytomegalovirus)
HCMV Host Cell Receptors [plasma membrane]
(Homo sapiens)
HCMV Tegumented Virion [viral tegument]
(Human cytomegalovirus)
HSPG [plasma membrane]
RL10 [plasma membrane]
(Human cytomegalovirus)
RL11 [plasma membrane]
(Human cytomegalovirus)
UL132 [plasma membrane]
(Human cytomegalovirus)
Participates
as an event of
HCMV Early Events (Homo sapiens)
Event Information
Go Biological Process
symbiont entry into host cell (0046718)
Disease
Name
Identifier
Synonyms
viral infectious disease
DOID:934
Viral disease, virus infection, virus infection
Authored
Gillespie, ME (2018-06-14)
Reviewed
Streblow, DN (2019-10-18)
Caposio, P (2019-10-18)
Created
Gillespie, ME (2018-06-15)
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