HCMV Early Events

Stable Identifier
R-HSA-9609690
Type
Pathway
Species
Homo sapiens
Related Species
Human cytomegalovirus
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
HCMV Early Events
Click the image above or here to open this pathway in the Pathway Browser

Once in the cytoplasm the capsid and tegument proteins are free to interact with host proteins. The capsid travels to the nucleus, where the genome is delivered and circularized. Tegument proteins regulate host cell responses and initiate the expression of viral I immediate early genes. This is followed by the expression of delayed early genes.

Literature References
PubMed ID Title Journal Year
21483467 Human Cytomegalovirus (HCMV) - Revised

von König, CH, Drosten, C, Blümel, J, Schlenkrich, U, Heiden, M, Burger, R, Jansen, B, Gürtler, L, Hildebrandt, M, Offergeld, R, Strobel, J, Pauli, G, Gröner, A, Schottstedt, V, Seitz, R, Montag-Lessing, T, Willkommen, H

Transfus Med Hemother 2010
25327590 The life cycle and pathogenesis of human cytomegalovirus infection: lessons from proteomics

Cristea, IM, Jean Beltran, PM

Expert Rev Proteomics 2014
  Fields Virology

Knipe, DM, Howley, PM

  2013
25894764 Human cytomegalovirus: taking the strain

Aicheler, R, Stanton, RJ, Wilkie, GS, Weekes, M, Murrell, I, Davison, AJ, Wilkinson, GW, Tomasec, P, Seirafian, S, Fielding, CA, Lehner, PJ, Wang, EC

Med. Microbiol. Immunol. 2015
Participants
Events
Participates
as an event of
Event Information
Go Biological Process
viral life cycle (0019058)
Disease
Name Identifier Synonyms
viral infectious disease DOID:934 Viral disease, virus infection, virus infection
Authored
Gillespie, ME  (2018-05-26)
Reviewed
Streblow, DN  (2019-10-18)
Caposio, P  (2019-10-18)
Created
Gillespie, ME  (2018-05-30)
Cite Us!