HCMV Early Events

Stable Identifier
R-HSA-9609690
Type
Pathway
Species
Homo sapiens
Related Species
Human cytomegalovirus
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HCMV Early Events
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Once in the cytoplasm the capsid and tegument proteins are free to interact with host proteins. The capsid travels to the nucleus, where the genome is delivered and circularized. Tegument proteins regulate host cell responses and initiate the expression of viral I immediate early genes. This is followed by the expression of delayed early genes.

Literature References
PubMed ID Title Journal Year
25327590 The life cycle and pathogenesis of human cytomegalovirus infection: lessons from proteomics

Jean Beltran, PM, Cristea, IM

Expert Rev Proteomics 2014
21483467 Human Cytomegalovirus (HCMV) - Revised

Schottstedt, V, Blümel, J, Burger, R, Drosten, C, Gröner, A, Gürtler, L, Heiden, M, Hildebrandt, M, Jansen, B, Montag-Lessing, T, Offergeld, R, Pauli, G, Seitz, R, Schlenkrich, U, Strobel, J, Willkommen, H, von König, CH

Transfus Med Hemother 2010
  Fields Virology

Knipe, DM, Howley, PM

  2013
25894764 Human cytomegalovirus: taking the strain

Wilkinson, GW, Davison, AJ, Tomasec, P, Fielding, CA, Aicheler, R, Murrell, I, Seirafian, S, Wang, EC, Weekes, M, Lehner, PJ, Wilkie, GS, Stanton, RJ

Med. Microbiol. Immunol. 2015
Participants
Events
Participant Of
hasEvent
Event Information
Go Biological Process
viral life cycle (0019058)
Disease
Name Identifier Synonyms
viral infectious disease 934 arbovirus infectious disease, Viral disease, Viral infection NOS, Viral infection, unspecified (disorder), Viral infection NOS, Viral disease (disorder), Viral disease, Viral infection NOS (disorder), Viral Infection, virus infection, virus infection, Viral: [infection NOS] or [illness]
Authored
Gillespie, ME  (2018-05-26)
Reviewed
Caposio, P  (2019-10-18)
Streblow, DN  (2019-10-18)
Created
Gillespie, ME  (2018-05-30)