The GluN1 (GRIN1) subunit of NMDA receptors binds to neurofilament light chain (NEFL, also known as NF-L), a type of cytoskeleton interfilaments, at postsynaptic density (PSD). Binding to NEFL may increase the stability of NMDA receptors at the PSD. Different GluN1 splicing isoforms may have different affinity for NEFL (Ehlers et al. 1998, Ratnam and Teichberg 2005). It is uncertain whether NEFL is a part of the core PSD (Dosemeci et al. 2007).
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