GluN1 (GRIN1) binds to NEFL at postsynaptic density

Stable Identifier
R-HSA-9610879
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
GluN1 (GRIN1) binds to NEFL at postsynaptic density
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
The GluN1 (GRIN1) subunit of NMDA receptors binds to neurofilament light chain (NEFL, also known as NF-L), a type of cytoskeleton interfilaments, at postsynaptic density (PSD). Binding to NEFL may increase the stability of NMDA receptors at the PSD. Different GluN1 splicing isoforms may have different affinity for NEFL (Ehlers et al. 1998, Ratnam and Teichberg 2005). It is uncertain whether NEFL is a part of the core PSD (Dosemeci et al. 2007).
Participants
Input
Output
Participates
as an event of
Inferred From
GluN1 (Grin1) binds Nefl (Rattus norvegicus)
Authored
Orlic-Milacic, M  (2019-01-05)
Reviewed
Traynelis, SF  (2019-02-11)
Camp, C  (2019-02-11)
Bhattacharya, S  (2019-02-11)
Created
Orlic-Milacic, M  (2018-06-13)
Cite Us!