Phosphorylated BTK phosphorylates PLCG2

Stable Identifier
R-HSA-9606162
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Phosphorylated BTK phosphorylates PLCG2
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Activated BTK (BTK phosphorylated on tyrosine-551 and tyrosine-223) bound to phosphorylated BLNK phosphorylates phospholipase gamma-2 (PKCG2) on tyrosines 753, 759, and 1217 (Rodriguez et al. 2001 and inferred from the rat homolog) thereby activating PLCG2 to hydrolyze phosphatidylinositol 4,5-bisphosphate, yielding the second messengers diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) (Carter et al. 1991, Roifman and Wang 1992, Kim et al. 2004, Sekiya et al. 2004). PLCG2 also binds phosphoinositol 3,4,5-trisphosphate (PIP3) produced by PI3K at the plasma membrane.

Literature References
PubMed ID Title Journal Year
1550550 Phospholipase C-gamma 1 and phospholipase C-gamma 2 are substrates of the B cell antigen receptor associated protein tyrosine kinase

Roifman, CM, Wang, G

Biochem Biophys Res Commun 1992
11606584 Tyrosine residues in phospholipase Cgamma 2 essential for the enzyme function in B-cell signaling

Rodriguez, R, Matsuda, M, Perisic, O, Bravo, J, Paul, A, Jones, NP, Light, Y, Swann, K, Williams, RL, Katan, M

J Biol Chem 2001
15509800 Mechanism of B-cell receptor-induced phosphorylation and activation of phospholipase C-gamma2

Kim, YJ, Sekiya, F, Poulin, B, Bae, YS, Rhee, SG

Mol Cell Biol 2004
15161916 Mechanism of tyrosine phosphorylation and activation of phospholipase C-gamma 1. Tyrosine 783 phosphorylation is not sufficient for lipase activation

Sekiya, F, Poulin, B, Kim, YJ, Rhee, SG

J Biol Chem 2004
2011584 Tyrosine phosphorylation of phospholipase C induced by membrane immunoglobulin in B lymphocytes

Carter, RH, Park, DJ, Rhee, SG, Fearon, DT

Proc Natl Acad Sci U S A 1991
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:p-Y223,Y551-BTK:NCK1:VAV1:PLCG2 [plasma membrane]
Physical Entity
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:p-Y223,Y551-BTK:NCK1:VAV1:PLCG2 [plasma membrane]
Activity
protein tyrosine kinase activity (0004713)
Inferred From
Phosphorylation of PLC-gamma (Rattus norvegicus)
Authored
May, B  (2018-04-14)
Reviewed
Wienands, J  (2018-07-18)
Created
May, B  (2018-04-19)
Cite Us!