Phosphorylation of PLC-gamma

Stable Identifier
R-RNO-2730881
Type
Reaction [transition]
Species
Rattus norvegicus
Compartment
General
SVG |   | PPTX  | SBGN
Phosphorylation of PLC-gamma

Tyrosine phosphorylation of PLC-gamma enhances its catalytic activity. BTK and SYK are involved in the phosphorylation of PLC-gamma (PLCG). Phosphorylation of tyrosine residues 753, 759, 1197, and 1217 in PLCG2 and 771, 783, and 1254 in PLCG1 have been identified as BTK/SYK-dependent phosphorylation sites.

Literature References
PubMed ID Title Journal Year
11507089 Four tyrosine residues in phospholipase C-gamma 2, identified as Btk-dependent phosphorylation sites, are required for B cell antigen receptor-coupled calcium signaling

Watanabe, D, Hashimoto, S, Ishiai, M, Matsushita, M, Baba, Y, Kishimoto, T, Kurosaki, T, Tsukada, S

J. Biol. Chem. 2001
15184383 Tec kinases mediate sustained calcium influx via site-specific tyrosine phosphorylation of the phospholipase Cgamma Src homology 2-Src homology 3 linker

Humphries, LA, Dangelmaier, C, Sommer, K, Kipp, K, Kato, RM, Griffith, N, Bakman, I, Turk, CW, Daniel, JL, Rawlings, DJ

J. Biol. Chem. 2004
20807769 Mechanism of phosphorylation-induced activation of phospholipase C-gamma isozymes

Gresset, A, Hicks, SN, Harden, TK, Sondek, J

J. Biol. Chem. 2010
Participants
Catalyst Activity

protein tyrosine kinase activity of Btk [cytosol]

Orthologous Events
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