Reactome | NME6 phosphorylates (d)NDPs to (d)NTPs

NME6 phosphorylates (d)NDPs to (d)NTPs

Stable Identifier

R-HSA-9605496

Type

Reaction [transition]

Species

Homo sapiens

Compartment

mitochondrial matrix

Synonyms

GDP + ATP => GTP + ADP, CDP + ATP => CTP + ADP, UDP + ATP => UTP + ADP, dADP + ATP => dATP + ADP, dGDP + ATP => dGTP + ADP, dCDP + ATP => dCTP + ADP, dTDP + ATP => dTTP + ADP, dUDP + ATP => dUTP + ADP

ReviewStatus

5/5

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Nucleoside diphosphate kinase 6 (NME6) is a mitochondrial protein (Tsuiki et al. 1999) that catalyses the reversible reaction of ribonucleoside and deoxyribonucleoside 5'-diphosphates ((d)NDP) with ATP to form the corresponding nucleoside 5'-triphosphates ((d)NTP) and ADP. NME6's protein sequence is only 34-41% identical to the five previously reported human NMEs. Its cDNA sequence includes the characteristic active site motif of a nucleoside diphosphate (NDP) kinase (Mehus et al. 1999). NME6 is lowly expressed in many human tissues, and is most abundant in kidney, prostate, ovary, intestine, and spleen.

Literature References

PubMed ID	Title	Journal	Year
10618642	A novel human nucleoside diphosphate (NDP) kinase, Nm23-H6, localizes in mitochondria and affects cytokinesis Tsuiki, H, Nitta, M, Furuya, A, Hanai, N, Fujiwara, T, Inagaki, M, Kochi, M, Ushio, Y, Saya, H, Nakamura, H	J. Cell. Biochem.	1999
10453732	NME6: a new member of the nm23/nucleoside diphosphate kinase gene family located on human chromosome 3p21.3 Mehus, JG, Deloukas, P, Lambeth, DO	Hum. Genet.	1999