Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 (ST6GALNAC6), located on the Golgi membrane, mediates the transfer of sialic acid (Neu5Ac) to Type 1 monosialylgalactosylgloboside (Type 1 MSGG) to form Type 1 disialylgalactosylgloboside (Type 1 DSGG), the precursor for disialyl-Lewis A antigen (Senda et al. 2007). ST6GALNAC6 and DSGG are found in proximal tubule epithelial cells in normal kidney tissues and are both downregulated in renal cancer cell lines and cancer tissues (Senda et al. 2007).
Ono, Y, Senda, M, Nakamura, Y, Tsuchida, A, Yoshikawa, K, Hagiwara, T, Katagiri, Y, Ogiso, M, Oshima, S, Kiso, M, Furukawa, K, Urano, T, Furukawa, K, Kasama, K, Kaneda, T, Ito, A
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity of ST6GALNAC6 [Golgi membrane]
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