ST6GALNAC6 transfers Neu5Ac to Type 1 MSGG to form Type 1 DSGG

Stable Identifier
R-HSA-9603991
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 (ST6GALNAC6), located on the Golgi membrane, mediates the transfer of sialic acid (Neu5Ac) to Type 1 monosialylgalactosylgloboside (Type 1 MSGG) to form Type 1 disialylgalactosylgloboside (Type 1 DSGG), the precursor for disialyl-Lewis A antigen (Senda et al. 2007). ST6GALNAC6 and DSGG are found in proximal tubule epithelial cells in normal kidney tissues and are both downregulated in renal cancer cell lines and cancer tissues (Senda et al. 2007).

Literature References
PubMed ID Title Journal Year
17123352 Identification and expression of a sialyltransferase responsible for the synthesis of disialylgalactosylgloboside in normal and malignant kidney cells: downregulation of ST6GalNAc VI in renal cancers

Senda, M, Ito, A, Tsuchida, A, Hagiwara, T, Kaneda, T, Nakamura, Y, Kasama, K, Kiso, M, Yoshikawa, K, Katagiri, Y, Ono, Y, Ogiso, M, Urano, T, Furukawa, K, Oshima, S, Furukawa, K

Biochem. J. 2007
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity of ST6GALNAC6 [Golgi membrane]
Physical Entity
Activity
Orthologous Events
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Created