Reactome | ST6GALNAC6 transfers Neu5Ac to Type 1 MSGG to form Type 1 DSGG

ST6GALNAC6 transfers Neu5Ac to Type 1 MSGG to form Type 1 DSGG

Stable Identifier

R-HSA-9603991

Type

Reaction [transition]

Species

Homo sapiens

Compartment

Golgi lumen, Golgi membrane

ReviewStatus

5/5

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ST6GALNAC6 transfers Neu5Ac to Type 1 MSGG to form Type 1 DSGG

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Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 (ST6GALNAC6), located on the Golgi membrane, mediates the transfer of sialic acid (Neu5Ac) to Type 1 monosialylgalactosylgloboside (Type 1 MSGG) to form Type 1 disialylgalactosylgloboside (Type 1 DSGG), the precursor for disialyl-Lewis A antigen (Senda et al. 2007). ST6GALNAC6 and DSGG are found in proximal tubule epithelial cells in normal kidney tissues and are both downregulated in renal cancer cell lines and cancer tissues (Senda et al. 2007).

Literature References

PubMed ID	Title	Journal	Year
17123352	Identification and expression of a sialyltransferase responsible for the synthesis of disialylgalactosylgloboside in normal and malignant kidney cells: downregulation of ST6GalNAc VI in renal cancers Ono, Y, Senda, M, Nakamura, Y, Tsuchida, A, Yoshikawa, K, Hagiwara, T, Katagiri, Y, Ogiso, M, Oshima, S, Kiso, M, Furukawa, K, Urano, T, Furukawa, K, Kasama, K, Kaneda, T, Ito, A	Biochem. J.	2007