Unknown caspase cleaves NTRK3

Stable Identifier
R-HSA-9603534
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
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In the absence of ligand, NTRK3 (TRKC) is cleaved by an unknown caspase. CASP3 (caspase-3) cleaves NTRK3 in vitro, but CASP3 inhibitors do not prevent NTRK3 cleavage in live cells. CASP8 (caspase-8) is unable to cleave NTRK3 in vitro. A general caspase inhibitor prevents NTRK3 cleavage in live cells (Tauszig-Delamasure et al. 2007).

Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
cysteine-type endopeptidase activity of unidentified caspase [cytosol]
Physical Entity
Activity
Inferred From
Authored
Reviewed
Created