NTRK3 as a dependence receptor

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Homo sapiens
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When neuronal cells are deprived of the NTRK3 (TRKC) ligand NTF3 (NT-3), NTRK3 functions as a dependence receptor, promoting apoptosis. The pro-apoptotic activity of NTRK3 is implicated in proper nervous system development, by dictating the number of surviving sensory neurons (Tauszig-Delamasure et al. 2007). In the absence of its ligand, NTRK3 undergoes caspase-dependent cleavage (Tauszig-Delamasure et al. 2007), resulting in release of the NTRK3 killer fragment (KF). The NTRK3 KF, in complex with NELFB (COBRA1), inserts into the mitochondrial membrane, promoting cytochrome c release and apoptosome-mediated apoptosis (Ichim et al. 2013).

Literature References
PubMed ID Title Journal Year
24034695 The dependence receptor TrkC triggers mitochondria-dependent apoptosis upon Cobra-1 recruitment

Ichim, G, Genevois, AL, Ménard, M, Yu, LY, Coelho-Aguiar, JM, Llambi, F, Jarrosson-Wuilleme, L, Lefebvre, J, Tulasne, D, Dupin, E, Le Douarin, N, Arumäe, U, Tauszig-Delamasure, S, Mehlen, P

Mol. Cell 2013
17686986 The TrkC receptor induces apoptosis when the dependence receptor notion meets the neurotrophin paradigm

Tauszig-Delamasure, S, Yu, LY, Cabrera, JR, Bouzas-Rodriguez, J, Mermet-Bouvier, C, Guix, C, Bordeaux, MC, Arumäe, U, Mehlen, P

Proc. Natl. Acad. Sci. U.S.A. 2007
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