NTRK3 as a dependence receptor

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R-HSA-9603505
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Homo sapiens
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When neuronal cells are deprived of the NTRK3 (TRKC) ligand NTF3 (NT-3), NTRK3 functions as a dependence receptor, promoting apoptosis. The pro-apoptotic activity of NTRK3 is implicated in proper nervous system development, by dictating the number of surviving sensory neurons (Tauszig-Delamasure et al. 2007). In the absence of its ligand, NTRK3 undergoes caspase-dependent cleavage (Tauszig-Delamasure et al. 2007), resulting in release of the NTRK3 killer fragment (KF). The NTRK3 KF, in complex with NELFB (COBRA1), inserts into the mitochondrial membrane, promoting cytochrome c release and apoptosome-mediated apoptosis (Ichim et al. 2013).

Literature References
PubMed ID Title Journal Year
17686986 The TrkC receptor induces apoptosis when the dependence receptor notion meets the neurotrophin paradigm

Cabrera, JR, Bouzas-Rodriguez, J, Bordeaux, MC, Tauszig-Delamasure, S, Mehlen, P, Yu, LY, Guix, C, Arumäe, U, Mermet-Bouvier, C

Proc. Natl. Acad. Sci. U.S.A. 2007
24034695 The dependence receptor TrkC triggers mitochondria-dependent apoptosis upon Cobra-1 recruitment

Mehlen, P, Coelho-Aguiar, JM, Arumäe, U, Lefebvre, J, Tulasne, D, Le Douarin, N, Llambi, F, Ichim, G, Jarrosson-Wuilleme, L, Genevois, AL, Tauszig-Delamasure, S, Yu, LY, Ménard, M, Dupin, E

Mol. Cell 2013
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