Reactome | Sulfhydrylation and ring cleavage of precursor Z

Sulfhydrylation and ring cleavage of precursor Z

Stable Identifier

R-HSA-947541

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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Sulfhydrylation and ring cleavage of precursor Z

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After the MOCS2A dimer is loaded with two sulfur atoms, their sequential deposition on the precursor Z molecule, with ring cleavage, is catalyzed by the MOCS2B half of the MOCS2 tetramer (Leimkuhler et al, 2003; Wuebbens & Rajagopalan, 2002).

Literature References

PubMed ID	Title	Journal	Year
12732628	Mechanistic studies of human molybdopterin synthase reaction and characterization of mutants identified in group B patients of molybdenum cofactor deficiency Freuer, A, Rajagopalan, KV, Araujo, JA, Mendel, RR, Leimkuhler, S	J Biol Chem	2003
12571226	Mechanistic and mutational studies of Escherichia coli molybdopterin synthase clarify the final step of molybdopterin biosynthesis Wuebbens, MM, Rajagopalan, KV	J Biol Chem	2003

Participants

Input

Output

Participates

as an event of

Molybdenum cofactor biosynthesis (Homo sapiens)

Catalyst Activity

molybdopterin synthase activity of 2xMOCS2-CO-S(1-):2xMOCS2B [cytosol]

Physical Entity

2xMOCS2-CO-S(1-):2xMOCS2B [cytosol] (Homo sapiens)

Activity

molybdopterin synthase activity (GO:0030366)

Authored

Stephan, R (2010-09-05)

Reviewed

D'Eustachio, P (2010-11-05)

Created

Jassal, B (2010-09-08)

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