Negative regulation of DDX58/IFIH1 signaling by RNF216

Stable Identifier
R-HSA-936475
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Related Species
Rotavirus, Influenza A virus, Hepatitis C Virus, Measles virus
Compartment
Synonyms
Negative regulation of RIG-I/MDA5 signaling by TRIAD3A
Locations in the PathwayBrowser
Summation

TRAF3 is dual regulated by DUBA (OTUD5) and TRIAD3A (RNF216). TRAF3 K63-polyubiquitin is removed by DUBA to disrupt TRAF3-TBK1/IKKi interactions. TRAF3 then undergoes a late phase K48-linked polyubiquitination by TRIAD3A, leading to TRAF3 proteasomal degradation. Thus TRIAD3A acts as a E3- ubiquitin ligase that negatively regulates RLR pathway.

Literature References
PubMed ID Title Journal Year
19893624 The E3 ubiquitin ligase Triad3A negatively regulates the RIG-I/MAVS signaling pathway by targeting TRAF3 for degradation

Nakhaei, P, Mesplede, T, Solis, M, Sun, Q, Zhao, T, Yang, L, Chuang, TH, Ware, CF, Lin, R, Hiscott, J

PLoS Pathog 2009
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
ubiquitin protein ligase activity of RNF216 [cytosol]
Physical Entity
Activity
Authored
Reviewed