Negative regulation of DDX58/IFIH1 signaling by RNF216

Stable Identifier
R-HSA-936475
Type
Reaction [omitted]
Species
Homo sapiens
Related Species
Influenza A virus, Human respiratory syncytial virus A, Rotavirus, Hepatitis C Virus, Measles virus
Compartment
mitochondrial outer membrane
Synonyms
Negative regulation of RIG-I/MDA5 signaling by TRIAD3A
ReviewStatus
5/5
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Negative regulation of DDX58/IFIH1 signaling by RNF216
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TRAF3 is dual regulated by DUBA (OTUD5) and TRIAD3A (RNF216). TRAF3 K63-polyubiquitin is removed by DUBA to disrupt TRAF3-TBK1/IKKi interactions. TRAF3 then undergoes a late phase K48-linked polyubiquitination by TRIAD3A, leading to TRAF3 proteasomal degradation. Thus TRIAD3A acts as a E3- ubiquitin ligase that negatively regulates RLR pathway.

Literature References
PubMed ID Title Journal Year
19893624 The E3 ubiquitin ligase Triad3A negatively regulates the RIG-I/MAVS signaling pathway by targeting TRAF3 for degradation

Hiscott, J, Lin, R, Zhao, T, Mesplede, T, Ware, CF, Chuang, TH, Nakhaei, P, Sun, Q, Solis, M, Yang, L

PLoS Pathog 2009
Participants
Input
Output
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as an event of
Catalyst Activity

ubiquitin protein ligase activity of RNF216 [cytosol]

Physical Entity
RNF216 [cytosol] (Homo sapiens)
Activity
ubiquitin protein ligase activity (GO:0061630)
Authored
Garapati, P V  (2010-08-02)
Reviewed
Akira, S  (2010-10-30)
Kawai, T  (2010-10-30)
Created
Garapati, P V  (2010-08-23)
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