Reactome | Negative regulators of DDX58/IFIH1 signaling

Negative regulators of DDX58/IFIH1 signaling

Stable Identifier

R-HSA-936440

Type

Pathway

Species

Homo sapiens

Related Species

Influenza A virus, Human respiratory syncytial virus A, Rotavirus, Hepatitis C Virus, Measles virus

Synonyms

Negative regulators of RIG-I/MDA5 signaling

ReviewStatus

5/5

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Negative regulators of DDX58/IFIH1 signaling

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As with other cytokine systems, production of type I IFN is a transient process, and can be hazardous to the host if unregulated, resulting in chronic cellular toxicity or inflammatory and autoimmune diseases. RIG-I-mediated production of IFN can, in turn, increase the transcription of RIG-I itself, thus setting into motion an IFN amplification loop, which if left unchecked, could become deleterious to the host. This module mainly focuses on the endogenous negative regulation of the RIG-I-like receptor (RLR) family proteins RIG-I and MDA5.

Literature References

PubMed ID	Title	Journal	Year
18549796	Regulation of mitochondrial antiviral signaling pathways Ting, JP, Moore, CB	Immunity	2008
18703349	Negative regulation of cytoplasmic RNA-mediated antiviral signaling Horvath, CM, Komuro, A, Bamming, D	Cytokine	2008