Negative regulators of DDX58/IFIH1 signaling

Stable Identifier
R-HSA-936440
Type
Pathway
Species
Homo sapiens
Related Species
Influenza A virus, Rotavirus, Hepatitis C Virus, Measles virus
Synonyms
Negative regulators of RIG-I/MDA5 signaling
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As with other cytokine systems, production of type I IFN is a transient process, and can be hazardous to the host if unregulated, resulting in chronic cellular toxicity or inflammatory and autoimmune diseases. RIG-I-mediated production of IFN can, in turn, increase the transcription of RIG-I itself, thus setting into motion an IFN amplification loop, which if left unchecked, could become deleterious to the host. This module mainly focuses on the endogenous negative regulation of the RIG-I-like receptor (RLR) family proteins RIG-I and MDA5.

Literature References
PubMed ID Title Journal Year
18549796 Regulation of mitochondrial antiviral signaling pathways

Ting, JP, Moore, CB

Immunity 2008
18703349 Negative regulation of cytoplasmic RNA-mediated antiviral signaling

Horvath, CM, Komuro, A, Bamming, D

Cytokine 2008
Participants
Participates
Event Information
Orthologous Events
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Reviewed
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