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holoTF [extracellular region]
Stable Identifier
R-HSA-917889
Type
Complex
Species
Homo sapiens
Compartment
extracellular region
Locations in the PathwayBrowser
Expand all
Transport of small molecules (Homo sapiens)
Iron uptake and transport (Homo sapiens)
Transferrin endocytosis and recycling (Homo sapiens)
TFR2 dimer binds 2xholoTF (Homo sapiens)
TFR2 dimer:2xholoTF [plasma membrane] (Homo sapiens)
holoTF [extracellular region] (Homo sapiens)
holoTF [extracellular region] (Homo sapiens)
TFRC dimer binds 2xholoTF (Homo sapiens)
holoTF [extracellular region] (Homo sapiens)
holoTF:TFRC dimer [plasma membrane] (Homo sapiens)
holoTF [extracellular region] (Homo sapiens)
holoTF:TFRC dimer translocates from plasma membrane to endosome membrane (Homo sapiens)
holoTF:TFRC dimer [plasma membrane] (Homo sapiens)
holoTF [extracellular region] (Homo sapiens)
apoTF binds 2Fe3+ to form holoTF (Homo sapiens)
holoTF [extracellular region] (Homo sapiens)
Vesicle-mediated transport (Homo sapiens)
Membrane Trafficking (Homo sapiens)
Clathrin-mediated endocytosis (Homo sapiens)
BAR domain proteins recruit dynamin (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
AP-2:cargo [plasma membrane] (Homo sapiens)
AP-2 cargo [plasma membrane] (Homo sapiens)
AP-2 YXXPhi cargo [plasma membrane] (Homo sapiens)
holoTF:TFRC dimer [plasma membrane] (Homo sapiens)
holoTF [extracellular region] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
AP-2:cargo [plasma membrane] (Homo sapiens)
AP-2 cargo [plasma membrane] (Homo sapiens)
AP-2 YXXPhi cargo [plasma membrane] (Homo sapiens)
holoTF:TFRC dimer [plasma membrane] (Homo sapiens)
holoTF [extracellular region] (Homo sapiens)
CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
AP-2:cargo [plasma membrane] (Homo sapiens)
AP-2 cargo [plasma membrane] (Homo sapiens)
AP-2 YXXPhi cargo [plasma membrane] (Homo sapiens)
holoTF:TFRC dimer [plasma membrane] (Homo sapiens)
holoTF [extracellular region] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
AP-2:cargo [plasma membrane] (Homo sapiens)
AP-2 cargo [plasma membrane] (Homo sapiens)
AP-2 YXXPhi cargo [plasma membrane] (Homo sapiens)
holoTF:TFRC dimer [plasma membrane] (Homo sapiens)
holoTF [extracellular region] (Homo sapiens)
Cargo recognition for clathrin-mediated endocytosis (Homo sapiens)
AP-2 directly binds some endocytic cargo (Homo sapiens)
AP-2 cargo [plasma membrane] (Homo sapiens)
AP-2 YXXPhi cargo [plasma membrane] (Homo sapiens)
holoTF:TFRC dimer [plasma membrane] (Homo sapiens)
holoTF [extracellular region] (Homo sapiens)
AP-2:cargo [plasma membrane] (Homo sapiens)
AP-2 cargo [plasma membrane] (Homo sapiens)
AP-2 YXXPhi cargo [plasma membrane] (Homo sapiens)
holoTF:TFRC dimer [plasma membrane] (Homo sapiens)
holoTF [extracellular region] (Homo sapiens)
Clathrin recruits PIK3C2A (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
AP-2:cargo [plasma membrane] (Homo sapiens)
AP-2 cargo [plasma membrane] (Homo sapiens)
AP-2 YXXPhi cargo [plasma membrane] (Homo sapiens)
holoTF:TFRC dimer [plasma membrane] (Homo sapiens)
holoTF [extracellular region] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
AP-2:cargo [plasma membrane] (Homo sapiens)
AP-2 cargo [plasma membrane] (Homo sapiens)
AP-2 YXXPhi cargo [plasma membrane] (Homo sapiens)
holoTF:TFRC dimer [plasma membrane] (Homo sapiens)
holoTF [extracellular region] (Homo sapiens)
Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
AP-2:cargo [plasma membrane] (Homo sapiens)
AP-2 cargo [plasma membrane] (Homo sapiens)
AP-2 YXXPhi cargo [plasma membrane] (Homo sapiens)
holoTF:TFRC dimer [plasma membrane] (Homo sapiens)
holoTF [extracellular region] (Homo sapiens)
Dynamin-mediated GTP hydrolysis promotes vesicle scission (Homo sapiens)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
AP-2:cargo [plasma membrane] (Homo sapiens)
AP-2 cargo [plasma membrane] (Homo sapiens)
AP-2 YXXPhi cargo [plasma membrane] (Homo sapiens)
holoTF:TFRC dimer [plasma membrane] (Homo sapiens)
holoTF [extracellular region] (Homo sapiens)
Endophilins recruit synaptojanins to the clathrin-coated pit (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
AP-2:cargo [plasma membrane] (Homo sapiens)
AP-2 cargo [plasma membrane] (Homo sapiens)
AP-2 YXXPhi cargo [plasma membrane] (Homo sapiens)
holoTF:TFRC dimer [plasma membrane] (Homo sapiens)
holoTF [extracellular region] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
AP-2:cargo [plasma membrane] (Homo sapiens)
AP-2 cargo [plasma membrane] (Homo sapiens)
AP-2 YXXPhi cargo [plasma membrane] (Homo sapiens)
holoTF:TFRC dimer [plasma membrane] (Homo sapiens)
holoTF [extracellular region] (Homo sapiens)
F- and N- BAR domain proteins bind the clathrin-coated pit (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
AP-2:cargo [plasma membrane] (Homo sapiens)
AP-2 cargo [plasma membrane] (Homo sapiens)
AP-2 YXXPhi cargo [plasma membrane] (Homo sapiens)
holoTF:TFRC dimer [plasma membrane] (Homo sapiens)
holoTF [extracellular region] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
AP-2:cargo [plasma membrane] (Homo sapiens)
AP-2 cargo [plasma membrane] (Homo sapiens)
AP-2 YXXPhi cargo [plasma membrane] (Homo sapiens)
holoTF:TFRC dimer [plasma membrane] (Homo sapiens)
holoTF [extracellular region] (Homo sapiens)
SNX9 recruits components of the actin polymerizing machinery (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
AP-2:cargo [plasma membrane] (Homo sapiens)
AP-2 cargo [plasma membrane] (Homo sapiens)
AP-2 YXXPhi cargo [plasma membrane] (Homo sapiens)
holoTF:TFRC dimer [plasma membrane] (Homo sapiens)
holoTF [extracellular region] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
AP-2:cargo [plasma membrane] (Homo sapiens)
AP-2 cargo [plasma membrane] (Homo sapiens)
AP-2 YXXPhi cargo [plasma membrane] (Homo sapiens)
holoTF:TFRC dimer [plasma membrane] (Homo sapiens)
holoTF [extracellular region] (Homo sapiens)
SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Homo sapiens)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
AP-2:cargo [plasma membrane] (Homo sapiens)
AP-2 cargo [plasma membrane] (Homo sapiens)
AP-2 YXXPhi cargo [plasma membrane] (Homo sapiens)
holoTF:TFRC dimer [plasma membrane] (Homo sapiens)
holoTF [extracellular region] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
AP-2:cargo [plasma membrane] (Homo sapiens)
AP-2 cargo [plasma membrane] (Homo sapiens)
AP-2 YXXPhi cargo [plasma membrane] (Homo sapiens)
holoTF:TFRC dimer [plasma membrane] (Homo sapiens)
holoTF [extracellular region] (Homo sapiens)
Participants
components
apoTF [extracellular region]
(Homo sapiens)
x 2
Fe3+ [extracellular region]
Participates
as a component of
TFR2 dimer:2xholoTF [plasma membrane] (Homo sapiens)
holoTF:TFRC dimer [plasma membrane] (Homo sapiens)
as an input of
TFR2 dimer binds 2xholoTF (Homo sapiens)
TFRC dimer binds 2xholoTF (Homo sapiens)
as an output of
apoTF binds 2Fe3+ to form holoTF (Homo sapiens)
Inferred To
holoTF [extracellular region]
(Bos taurus)
holoTF [extracellular region]
(Drosophila melanogaster)
holoTF [extracellular region]
(Gallus gallus)
holoTF [extracellular region]
(Mus musculus)
holoTF [extracellular region]
(Rattus norvegicus)
holoTF [extracellular region]
(Sus scrofa)
holoTF [extracellular region]
(Xenopus tropicalis)
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