The SHC1:SHIP1 complex is stabilized by GRB2

Stable Identifier
R-HSA-913424
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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The SHC1:SHIP1 complex is stabilized by GRB2
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Grb2 stabilizes the Shc/SHIP complex (Harmer & DeFranco 1999), presumably by simultaneously binding via its SH3 domains to SHIP and via its SH2 domain to phosphotyrosines on Shc. This forms a ternary complex of SHC1:GRB2:SHIP described as an outcome of IL-3, IL-5 or GM-CSF stimulation (Lafrancone et al. 1995, Odai et al. 1997). SHIP2 also associates with SHC1 but does not appear to require Grb2 for stability (Wisniewskiet al. 1999).
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Orthologous Events
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Authored
Ray, KP  (2010-05-17)
Reviewed
Dooms, H  (2011-03-17)
Villarino, A  (2011-02-11)
Created
Jupe, S  (2010-07-14)
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