The SHC1:SHIP1 complex is stabilized by GRB2

Stable Identifier
R-HSA-913424
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
The SHC1:SHIP1 complex is stabilized by GRB2
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Grb2 stabilizes the Shc/SHIP complex (Harmer & DeFranco 1999), presumably by simultaneously binding via its SH3 domains to SHIP and via its SH2 domain to phosphotyrosines on Shc. This forms a ternary complex of SHC1:GRB2:SHIP described as an outcome of IL-3, IL-5 or GM-CSF stimulation (Lafrancone et al. 1995, Odai et al. 1997). SHIP2 also associates with SHC1 but does not appear to require Grb2 for stability (Wisniewskiet al. 1999).
Literature References
Participants
Input
Output
Participates
as an event of
Orthologous Events
The SHC1:SHIP1 complex is stabilized by GRB2 (Bos taurus)
The SHC1:SHIP1 complex is stabilized by GRB2 (Canis familiaris)
The SHC1:SHIP1 complex is stabilized by GRB2 (Gallus gallus)
The SHC1:SHIP1 complex is stabilized by GRB2 (Mus musculus)
The SHC1:SHIP1 complex is stabilized by GRB2 (Rattus norvegicus)
The SHC1:SHIP1 complex is stabilized by GRB2 (Sus scrofa)
Authored
Ray, KP  (2010-05-17)
Reviewed
Villarino, A  (2011-02-11)
Dooms, H  (2011-03-17)
Created
Jupe, S  (2010-07-14)
Cite Us!