Upon activation by NTF3 (NT-3), the receptor tyrosine kinase NTRK3 (TRKC) triggers RAS signaling through adaptor proteins SHC1 and GRB2 (Marsh and Palfrey 1996, Gunn-Moore et al. 1997, Yuen and Mobley 1999). ERK activation downstream of NTRK3 may increase cell motility through WAVE. The mechanism is not known (Gromnitza et al. 2018).
Gromnitza, S, Lepa, C, Weide, T, Schwab, A, Pavenstädt, H, George, B
Marsh, HN, Palfrey, HC
Gunn-Moore, FJ, Williams, AG, Tavaré, JM
Yuen, EC, Mobley, WC
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