Activated NTRK3 signals through RAS

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Homo sapiens
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Upon activation by NTF3 (NT-3), the receptor tyrosine kinase NTRK3 (TRKC) triggers RAS signaling through adaptor proteins SHC1 and GRB2 (Marsh and Palfrey 1996, Gunn-Moore et al. 1997, Yuen and Mobley 1999). ERK activation downstream of NTRK3 may increase cell motility through WAVE. The mechanism is not known (Gromnitza et al. 2018).

Literature References
PubMed ID Title Journal Year
29162704 Tropomyosin-related kinase C (TrkC) enhances podocyte migration by ERK-mediated WAVE2 activation

Gromnitza, S, Lepa, C, Weide, T, Schwab, A, Pavenstädt, H, George, B

FASEB J. 2018
8752100 Neurotrophin-3 and brain-derived neurotrophic factor activate multiple signal transduction events but are not survival factors for hippocampal pyramidal neurons

Marsh, HN, Palfrey, HC

J. Neurochem. 1996
9078261 Analysis of mitogen-activated protein kinase activation by naturally occurring splice variants of TrkC, the receptor for neurotrophin-3

Gunn-Moore, FJ, Williams, AG, Tavaré, JM

Biochem. J. 1997
10486198 Early BDNF, NT-3, and NT-4 signaling events

Yuen, EC, Mobley, WC

Exp. Neurol. 1999
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