USP9X binds Ub:PEX5L

Stable Identifier
R-HSA-9033509
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
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USP9X binds Ub:PEX5L
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The deubiquitinating enzyme USP9X binds ubiquitinated PEX5L (ubiquitin conjugated to the large isoform of PEX5, Ub:PEX5L) and then hydrolyzes the thioester bond between the carboxyl terminus of ubiquitin and cysteine-11 of PEX5L (Grou et al. 2012).

Literature References
PubMed ID Title Journal Year
22371489 Identification of ubiquitin-specific protease 9X (USP9X) as a deubiquitinase acting on ubiquitin-peroxin 5 (PEX5) thioester conjugate

Grou, CP, Francisco, T, Rodrigues, TA, Freitas, MO, Pinto, MP, Carvalho, AF, Domingues, P, Wood, SA, Rodríguez-Borges, JE, Sá-Miranda, C, Fransen, M, Azevedo, JE

J. Biol. Chem. 2012
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Orthologous Events
USP9X binds Ub:PEX5L (Bos taurus)
USP9X binds Ub:PEX5L (Canis familiaris)
USP9X binds Ub:PEX5L (Danio rerio)
USP9X binds Ub:PEX5L (Dictyostelium discoideum)
USP9X binds Ub:PEX5L (Drosophila melanogaster)
USP9X binds Ub:PEX5L (Gallus gallus)
USP9X binds Ub:PEX5L (Mus musculus)
USP9X binds Ub:PEX5L (Rattus norvegicus)
USP9X binds Ub:PEX5L (Sus scrofa)
USP9X binds Ub:PEX5L (Xenopus tropicalis)
USP9X binds Ub:PEX5S (Homo sapiens)
Authored
May, B  (2017-12-20)
Reviewed
Fransen, M  (2018-02-13)
Van Veldhoven, PP  (2018-02-13)
Azevedo, JE  (2018-03-12)
Created
May, B  (2017-12-22)