USP9X binds Ub:PEX5L

Stable Identifier
R-HSA-9033509
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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USP9X binds Ub:PEX5L
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
The deubiquitinating enzyme USP9X binds ubiquitinated PEX5L (ubiquitin conjugated to the large isoform of PEX5, Ub:PEX5L) and then hydrolyzes the thioester bond between the carboxyl terminus of ubiquitin and cysteine-11 of PEX5L (Grou et al. 2012).
Literature References
PubMed ID Title Journal Year
22371489 Identification of ubiquitin-specific protease 9X (USP9X) as a deubiquitinase acting on ubiquitin-peroxin 5 (PEX5) thioester conjugate

Domingues, P, Sá-Miranda, C, Rodrigues, TA, Freitas, MO, Grou, CP, Carvalho, AF, Wood, SA, Azevedo, JE, Pinto, MP, Rodríguez-Borges, JE, Fransen, M, Francisco, T

J. Biol. Chem. 2012
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Orthologous Events
USP9X binds Ub:PEX5L (Bos taurus)
USP9X binds Ub:PEX5L (Caenorhabditis elegans)
USP9X binds Ub:PEX5L (Dictyostelium discoideum)
USP9X binds Ub:PEX5L (Drosophila melanogaster)
USP9X binds Ub:PEX5L (Gallus gallus)
USP9X binds Ub:PEX5L (Mus musculus)
USP9X binds Ub:PEX5L (Sus scrofa)
USP9X binds Ub:PEX5L (Xenopus tropicalis)
USP9X binds Ub:PEX5S (Homo sapiens)
Authored
May, B  (2017-12-20)
Reviewed
Van Veldhoven, PP  (2018-02-13)
Fransen, M  (2018-02-13)
Azevedo, JE  (2018-03-12)
Created
May, B  (2017-12-22)
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