USP9X binds Ub:PEX5S

Stable Identifier
R-HSA-9033526
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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USP9X binds Ub:PEX5S
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
The deubiquitinating enzyme USP9X binds cytosolic ubiquitinated PEX5S (Ub:PEX5S) and then hydrolyzes the thioester bond between the carboxyl terminus of ubiquitin and cysteine-11 of PEX5S (inferred from the large isoform of PEX5 in Grou et al. 2012).
Literature References
PubMed ID Title Journal Year
22371489 Identification of ubiquitin-specific protease 9X (USP9X) as a deubiquitinase acting on ubiquitin-peroxin 5 (PEX5) thioester conjugate

Domingues, P, Sá-Miranda, C, Rodrigues, TA, Freitas, MO, Grou, CP, Carvalho, AF, Wood, SA, Azevedo, JE, Pinto, MP, Rodríguez-Borges, JE, Fransen, M, Francisco, T

J. Biol. Chem. 2012
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Inferred From
USP9X binds Ub:PEX5L (Homo sapiens)
Authored
May, B  (2017-12-20)
Reviewed
Van Veldhoven, PP  (2018-02-13)
Fransen, M  (2018-02-13)
Azevedo, JE  (2018-03-12)
Created
May, B  (2017-12-22)
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