PEX5L binds PEX7:Cargo protein

Stable Identifier
R-HSA-9033240
Type
Reaction [binding]
Species
Homo sapiens
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The long isoform of PEX5, PEX5L, binds PEX7 that is already bound to a PTS2-containing cargo protein (Braverman et al. 1998, Dodt et al. 2001, Kunze et al. 2015, Rodrigues et al. 2015). The binding of PEX5L to PEX7 increases the affinity of PEX7 for cargo protein (Kunze et al. 2015). Mutations affecting the additional sequence present only in the long isoform of PEX5 cause rhizomelic chondrodysplasia punctata type 5 (Baroy et al. 2015).

Literature References
PubMed ID Title Journal Year
25538232 Mechanistic insights into PTS2-mediated peroxisomal protein import: the co-receptor PEX5L drastically increases the interaction strength between the cargo protein and the receptor PEX7

Kunze, M, Malkani, N, Maurer-Stroh, S, Wiesinger, C, Schmid, JA, Berger, J

J. Biol. Chem. 2015
26220973 A novel type of rhizomelic chondrodysplasia punctata, RCDP5, is caused by loss of the PEX5 long isoform

Barøy, T, Koster, J, Strømme, P, Ebberink, MS, Misceo, D, Ferdinandusse, S, Holmgren, A, Hughes, T, Merckoll, E, Westvik, J, Woldseth, B, Walter, J, Wood, N, Tvedt, B, Stadskleiv, K, Wanders, RJ, Waterham, HR, Frengen, E

Hum. Mol. Genet. 2015
9668159 An isoform of pex5p, the human PTS1 receptor, is required for the import of PTS2 proteins into peroxisomes

Braverman, N, Dodt, G, Gould, SJ, Valle, D

Hum. Mol. Genet. 1998
26138649 Revisiting the intraperoxisomal pathway of mammalian PEX7

Rodrigues, TA, Grou, CP, Azevedo, JE

Sci Rep 2015
11546814 Domain mapping of human PEX5 reveals functional and structural similarities to Saccharomyces cerevisiae Pex18p and Pex21p

Dodt, G, Warren, D, Becker, E, Rehling, P, Gould, SJ

J. Biol. Chem. 2001
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