NTRK2 activates RAS signaling through FRS2

Stable Identifier
R-HSA-9032067
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
NTRK2 activates RAS signaling through FRS2
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
FRS2 is involved in TRKB-mediated activation of RAS signaling. The exact mechanism has not been elucidated. It is likely that SOS1, in complex with GRB2, recruited to activated NTRK2 (TRKB) receptor through phosphorylated FRS2, catalyzes guanine nucleotide exchange on RAS (HRAS, KRAS or NRAS), resulting in formation of the active RAS:GTP complex and initiation of RAS/RAF/MAPK signaling. PTPN11 (SHP2) facilitates FRS2-mediated activation of RAS downstream of NTRK2, possibly by contributing to GRB2 recruitment (Easton et al. 1999, Easton et al. 2006).
Participants
Input
Output
Participates
as an event of
Catalyst Activity

guanyl-nucleotide exchange factor activity of BDNF,NTF4:p-5Y-NTRK2:p-Y-FRS2:GRB2-1:SOS1 [plasma membrane]

Physical Entity
BDNF,NTF4:p-5Y-NTRK2:p-Y-FRS2:GRB2-1:SOS1 [plasma membrane] (Homo sapiens)
Activity
guanyl-nucleotide exchange factor activity (GO:0005085)
This event is regulated
Positively by
Regulator
BDNF,NTF4:p-5Y-NTRK2:p-Y-FRS2:PTPN11 [plasma membrane] (Homo sapiens)
Inferred From
Ntrk2 activates Ras signaling through Frs2 (Homo sapiens)
Authored
Orlic-Milacic, M  (2018-01-05)
Reviewed
Antila, H  (2018-02-13)
Castrén, E  (2018-02-13)
Created
Orlic-Milacic, M  (2017-12-05)
Cite Us!