Reactome | NCOA1 binds the UGT1A3 gene:NR1H2,3:RXR:NR1H2,3 ligand complex

NCOA1 binds the UGT1A3 gene:NR1H2,3:RXR:NR1H2,3 ligand complex

Stable Identifier

R-HSA-9029580

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

NCOA1 binds the UGT1A3 gene:LXR:RXR:LXR ligand complex

ReviewStatus

5/5

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NCOA1 binds the UGT1A3 gene:NR1H2,3:RXR:NR1H2,3 ligand complex

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In transient transfection assays performed in human hepatoma HepG2 cells, NR1H3 (LXR alpha) was found to interact with the NCOA1 (SRC1) and NCOR cofactors to regulate the UGT1A3 gene promoter (Verreault M et al. 2006). Unliganded LXR:RXR actively suppresses transcription by recruiting the co-repressor NCOR complex. Agonist binding induces dissociation of the co-repressor, which results in moderate stimulation of transcription and later recruits co-activators such as NCOA1 leading to maximal stimulation of transcription.

Literature References

PubMed ID	Title	Journal	Year
16871576	The liver X-receptor alpha controls hepatic expression of the human bile acid-glucuronidating UGT1A3 enzyme in human cells and transgenic mice Verreault, M, Senekeo-Effenberger, K, Trottier, J, Bonzo, JA, Bélanger, J, Kaeding, J, Staels, B, Caron, P, Tukey, RH, Barbier, O	Hepatology	2006