Reactome | p-S363,S380,T573 RS6K translocates to the nucleus

p-S363,S380,T573 RS6K translocates to the nucleus

Stable Identifier

R-HSA-9029434

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

Locations in the PathwayBrowser

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Neuronal System (Homo sapiens)

- Transmission across Chemical Synapses (Homo sapiens)
  - Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
    - Activation of NMDA receptors and postsynaptic events (Homo sapiens)
      - Post NMDA receptor activation events (Homo sapiens)
        
        CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling (Homo sapiens)
        
        RSK activation (Homo sapiens)
        
        p-S363,S380,T573 RS6K translocates to the nucleus (Homo sapiens)

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p-S363,S380,T573 RS6K translocates to the nucleus

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Inactive 90 kDa ribosomal S6 kinases (RSKs) can be detected in both the cytosol and the nucleus (Chen et al. 1992). Based on the available experimental evidence, it is most likely that activation of RSKs happens in the vicinity of the plasma membrane and that active RSKs then translocate to the nucleus (Chen et al. 1992, Smith et al. 1999, Richards et al. 2001, Murphy et al. 2002), but there is a possibility that activation of RSKs can also occur in the nucleus (Chen et al. 1992, reviewed in Anjum and Blenis 2012).

Literature References

PubMed ID	Title	Journal	Year
18813292	The RSK family of kinases: emerging roles in cellular signalling Anjum, R, Blenis, J	Nat Rev Mol Cell Biol	2008
9915826	Identification of an extracellular signal-regulated kinase (ERK) docking site in ribosomal S6 kinase, a sequence critical for activation by ERK in vivo Smith, JA, Poteet-Smith, CE, Malarkey, K, Sturgill, TW	J. Biol. Chem.	1999
11585927	Characterization of regulatory events associated with membrane targeting of p90 ribosomal S6 kinase 1 Richards, SA, Dreisbach, VC, Murphy, LO, Blenis, J	Mol. Cell. Biol.	2001