Reactome | PTGS2 dimer oxidises DPAn-3 to 13(R)-HDPAn-3

PTGS2 dimer oxidises DPAn-3 to 13(R)-HDPAn-3

Stable Identifier

R-HSA-9026408

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, endoplasmic reticulum membrane

Synonyms

(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + AH2 + O2 => 13R-hydroxy-(7Z,10Z,14E,16Z,19Z)-docosapentaenoate + A + H2O

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

PTGS2 dimer oxidises DPAn-3 to 13(R)-HDPAn-3

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Incubation of ω-3 docosapentaenoic acid (DPAn-3) with human recombinant cyclooxygenase 2 (PTGS2 dimer, COX2) in vascular endothelial cells produces 13(R)-hydroxy-docasapentaenoic acid (13(R)-HDPAn-3), the precursor of 13(R)-resolvins and the electrophilic 13-oxo-DPAn-3 (Dalli et al. 2015, Primdahl et al. 2016).

Literature References

PubMed ID	Title	Journal	Year
26236990	Elucidation of novel 13-series resolvins that increase with atorvastatin and clear infections Dalli, J, Chiang, N, Serhan, CN	Nat. Med.	2015
27704804	Synthesis of 13(R)-Hydroxy-7Z,10Z,13R,14E,16Z,19Z Docosapentaenoic Acid (13R-HDPA) and Its Biosynthetic Conversion to the 13-Series Resolvins Primdahl, KG, Aursnes, M, Walker, ME, Colas, RA, Serhan, CN, Dalli, J, Hansen, TV, Vik, A	J. Nat. Prod.	2016

Participants

Input

Output

Participates

as an event of

Biosynthesis of DPAn-3 SPMs (Homo sapiens)

Catalyst Activity

oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen of PTGS2 dimer [endoplasmic reticulum membrane]

Physical Entity

PTGS2 dimer [endoplasmic reticulum membrane] (Homo sapiens)

Activity

oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen (GO:0016702)

Orthologous Events

PTGS2 dimer oxidises DPAn-3 to 13(R)-HDPAn-3 (Bos taurus)

PTGS2 dimer oxidises DPAn-3 to 13(R)-HDPAn-3 (Canis familiaris)

PTGS2 dimer oxidises DPAn-3 to 13(R)-HDPAn-3 (Danio rerio)

PTGS2 dimer oxidises DPAn-3 to 13(R)-HDPAn-3 (Gallus gallus)

PTGS2 dimer oxidises DPAn-3 to 13(R)-HDPAn-3 (Mus musculus)

PTGS2 dimer oxidises DPAn-3 to 13(R)-HDPAn-3 (Rattus norvegicus)

PTGS2 dimer oxidises DPAn-3 to 13(R)-HDPAn-3 (Sus scrofa)