Reactome | Biosynthesis of DPAn-3 SPMs

Biosynthesis of DPAn-3 SPMs

Stable Identifier

R-HSA-9025094

Type

Pathway

Species

Homo sapiens

ReviewStatus

5/5

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The polyunsaturated fatty acid (PUFA) ω-3 cis-7,10,13,16,19-docosapentaenoic acid (DPAn-3) is an intermediate in the biosynthesis of docosahexaenoic acid (DHA) from eicosapentaenoic acid (EPA) and is also a precursor for the production of novel bioactive mediators. The proposed biosynthesis of specialised proresolving mediators (SPMs) derived from DPAn-3 is described here (Dalli et al. 2013, Hansen et al. 2017, Vik et al. 2017). The products of the ω-3 isomer were characterised based on DHA (docosahexaenoic acid) derived resolvins, protectins and maresins (Serhan et al. 2002, Bannenberg & Serhan 2010). The same biosynthetic route as DHA-derived SPMs is probably how DPAn-3 products are also formed (Dalli et al. 2013).

Literature References

PubMed ID	Title	Journal	Year
23736886	Novel n-3 immunoresolvents: structures and actions Dalli, J, Colas, RA, Serhan, CN	Sci Rep	2013
28602942	The novel lipid mediator PD1n-3 DPA: An overview of the structural elucidation, synthesis, biosynthesis and bioactions Hansen, TV, Dalli, J, Serhan, CN	Prostaglandins Other Lipid Mediat.	2017
28408222	Recent advances in the chemistry and biology of anti-inflammatory and specialized pro-resolving mediators biosynthesized from n-3 docosapentaenoic acid Vik, A, Dalli, J, Hansen, TV	Bioorg. Med. Chem. Lett.	2017