ALOX15 oxidises DPAn-3 to 17(S)-Hp-DPAn-3

Stable Identifier
R-HSA-9026003
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

At sites of injury, 15 lipoxygenase (ALOX15) can oxygenate ω-3 docosapentaenoic acid (DPAn-3) to form the 17(S) epimer 17(S)-hydroperoxy docosapentaenoic acid (17(S)-Hp-DPAn-3) in neutrophils (Dalli et al. 2013). The formations of individual hydroperoxy intermediates are supported by chemical synthesis experiments (Aursnes et al. 2014, Primdahl et al. 2017) and are the pivotal intermediates in the production of DPAn-3 derived protectins and resolvins.

Literature References
PubMed ID Title Journal Year
24576195 Total synthesis of the lipid mediator PD1n-3 DPA: configurational assignments and anti-inflammatory and pro-resolving actions

Aursnes, M, Tungen, JE, Vik, A, Colas, RA, Cheng, CY, Dalli, J, Serhan, CN, Hansen, TV

J. Nat. Prod. 2014
23736886 Novel n-3 immunoresolvents: structures and actions

Dalli, J, Colas, RA, Serhan, CN

Sci Rep 2013
28980694 Stereocontrolled synthesis and investigation of the biosynthetic transformations of 16(S),17(S)-epoxy-PDn-3 DPA

Primdahl, KG, Tungen, JE, De Souza, PRS, Colas, RA, Dalli, J, Hansen, TV, Vik, A

Org. Biomol. Chem. 2017
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
arachidonate 15-lipoxygenase activity of ALOX15 [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created
Cite Us!