ALOX15 oxidises DPAn-3 to 17(S)-Hp-DPAn-3

Stable Identifier
Reaction [transition]
Homo sapiens
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At sites of injury, 15 lipoxygenase (ALOX15) can oxygenate ω-3 docosapentaenoic acid (DPAn-3) to form the 17(S) epimer 17(S)-hydroperoxy docosapentaenoic acid (17(S)-Hp-DPAn-3) in neutrophils (Dalli et al. 2013). The formations of individual hydroperoxy intermediates are supported by chemical synthesis experiments (Aursnes et al. 2014, Primdahl et al. 2017) and are the pivotal intermediates in the production of DPAn-3 derived protectins and resolvins.

Literature References
PubMed ID Title Journal Year
23736886 Novel n-3 immunoresolvents: structures and actions

Serhan, CN, Colas, RA, Dalli, J

Sci Rep 2013
24576195 Total synthesis of the lipid mediator PD1n-3 DPA: configurational assignments and anti-inflammatory and pro-resolving actions

Serhan, CN, Colas, RA, Cheng, CY, Hansen, TV, Tungen, JE, Aursnes, M, Vik, A, Dalli, J

J. Nat. Prod. 2014
28980694 Stereocontrolled synthesis and investigation of the biosynthetic transformations of 16(S),17(S)-epoxy-PDn-3 DPA

Colas, RA, Hansen, TV, Tungen, JE, Vik, A, Dalli, J, Primdahl, KG, De Souza, PRS

Org. Biomol. Chem. 2017
Catalyst Activity

arachidonate 15-lipoxygenase activity of ALOX15 [cytosol]

Orthologous Events
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