LYN phosphorylates CRKL in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:CRKL:RAPGEF1

Stable Identifier
R-HSA-9024726
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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LYN, in a complex with EPOR, phosphorylates CRKL bound to RAPGEF1 (Arai et al. 2001).

Literature References
PubMed ID Title Journal Year
11443118 CrkL is recruited through its SH2 domain to the erythropoietin receptor and plays a role in Lyn-mediated receptor signaling

Arai, A, Kanda, E, Nosaka, Y, Miyasaka, N, Miura, O

J. Biol. Chem. 2001
Participants
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Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:CRKL:RAPGEF1 [plasma membrane]
Physical Entity
Activity
Inferred From
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