PTPN1 gene expression is inhibited by MECP2

Stable Identifier
R-HSA-9023549
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
PTPN1 gene expression is inhibited by MECP2
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
MECP2 directly represses PTPN1 (PTP1B) gene transcription in both human and mouse cells (Krishnan et al. 2015). PTPN1 can dephosphorylated BDNF receptor TRKB, which negatively regulates BDNF signaling. Increased PTPN1 level, which is a consequence of the loss of function of MECP2, interferes with BDNF signaling (Krishnan et al. 2015).
Literature References
PubMed ID Title Journal Year
26214522 PTP1B inhibition suggests a therapeutic strategy for Rett syndrome

Connors, CR, Krishnan, K, Shea, SD, Krishnan, N, Tonks, NK, Van Aelst, L, Choy, MS, Peti, W, Page, R

J. Clin. Invest. 2015
Participants
Input
Output
Participates
as an event of
This event is regulated
Negatively by
Regulator
MECP2:PTPN1 gene [nucleoplasm] (Homo sapiens)
Active Unit
MECP2 [nucleoplasm]
Authored
Orlic-Milacic, M  (2017-10-02)
Reviewed
Krishnaraj, R  (2018-08-07)
Christodoulou, J  (2018-08-07)
Created
Orlic-Milacic, M  (2017-09-27)
Cite Us!