PTPN1 gene expression is inhibited by MECP2

Stable Identifier
R-HSA-9023549
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, cytosol
ReviewStatus
5/5
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PTPN1 gene expression is inhibited by MECP2
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MECP2 directly represses PTPN1 (PTP1B) gene transcription in both human and mouse cells (Krishnan et al. 2015). PTPN1 can dephosphorylated BDNF receptor TRKB, which negatively regulates BDNF signaling. Increased PTPN1 level, which is a consequence of the loss of function of MECP2, interferes with BDNF signaling (Krishnan et al. 2015).
Literature References
PubMed ID Title Journal Year
26214522 PTP1B inhibition suggests a therapeutic strategy for Rett syndrome

Krishnan, N, Krishnan, K, Connors, CR, Choy, MS, Page, R, Peti, W, Van Aelst, L, Shea, SD, Tonks, NK

J. Clin. Invest. 2015
Participants
Input
Output
Participates
as an event of
This event is regulated
Negatively by
Regulator
MECP2:PTPN1 gene [nucleoplasm] (Homo sapiens)
Active Unit
MECP2 [nucleoplasm]
Authored
Orlic-Milacic, M  (2017-10-02)
Reviewed
Krishnaraj, R  (2018-08-07)
Christodoulou, J  (2018-08-07)
Created
Orlic-Milacic, M  (2017-09-27)
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