MECP2 directly represses PTPN1 (PTP1B) gene transcription in both human and mouse cells (Krishnan et al. 2015). PTPN1 can dephosphorylated BDNF receptor TRKB, which negatively regulates BDNF signaling. Increased PTPN1 level, which is a consequence of the loss of function of MECP2, interferes with BDNF signaling (Krishnan et al. 2015).
Krishnan, N, Krishnan, K, Connors, CR, Choy, MS, Page, R, Peti, W, Van Aelst, L, Shea, SD, Tonks, NK
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